Two Onc Docs Soft Tissue Sarcomas 2025 UPDATE
Sep 9, 2025
Delve into the latest insights on soft tissue sarcomas, featuring new FDA approvals and evolving diagnostic challenges. Discover the complexities of this rare category of tumors, which represent just 1% of adult cancers and include both noncancerous and aggressive forms. Learn about treatment strategies for various subtypes, including desmoid tumors and Kaposi's sarcoma, highlighting innovative surgical and chemotherapy advancements. The emphasis is on a multidisciplinary approach to enhance patient outcomes.
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Sarcomas Are Rare And Diverse
- Soft tissue sarcomas are rare, diverse tumors arising from mesenchymal cells and represent ~1% of adult cancers.
- There are 50–100 subtypes and molecular classification is rapidly evolving.
Use Core Needle Biopsy, Not FNA
- Obtain a core needle biopsy for suspected sarcoma to preserve tissue architecture for diagnosis.
- Avoid fine needle aspiration because it does not provide sufficient information.
Image Primary And Chest For Staging
- Stage extremity/trunk sarcomas with MRI of the primary site and at minimum a CT chest to check for lung metastases.
- Consider PET, bone scans, or spine imaging for selected subtypes like myxoid liposarcoma.