Two Onc Docs Esophageal and Gastrosophageal Junction (GEJ) Cancer 2025 UPDATE
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Sep 29, 2025 Get ready to dive into the complex world of esophageal and gastroesophageal junction cancers! Discover the symptoms like dysphagia and hoarseness, and learn how to differentiate cancer types based on location. Uncover the risk factors for squamous versus adenocarcinoma. The discussion also covers the latest diagnostic techniques and staging criteria. Explore treatment options from endoscopic resection to cutting-edge chemotherapy regimens. Don't miss the insights on managing metastatic disease and key trials shaping future therapies!
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Location Drives Histology And Management
- Squamous carcinoma usually arises in the upper third of the esophagus while adenocarcinoma affects the lower esophagus and GE junction.
- Anatomical location plus histology guide treatment choices and surgical planning.
Recognize Red-Flag Symptoms Early
- Watch for progressive dysphagia, weight loss, reflux, epigastric pain, bleeding, cough, and hoarseness.
- Escalating solids-to-liquids dysphagia warrants prompt evaluation with endoscopy.
Different Risk Profiles By Histology
- Squamous risk factors include smoking, alcohol, nitrate-rich diets, prior radiation, and structural abnormalities.
- Adenocarcinoma links to obesity, chronic reflux, Barrett's esophagus, and high-grade dysplasia with high annual transformation risk.