Two Onc Docs

October marks Breast Cancer Awareness Month, making this a timely discussion. Key topics include breast cancer risk factors, when to get genetic testing, and screening recommendations for high-risk individuals. They delve into the management of LCIS and DCIS, detailing treatment options like mastectomy versus lumpectomy. Insights on chemoprevention, tamoxifen's side effects, and the challenges of rare breast histologies are also explored. Plus, learn the basics of staging and when axillary dissection is necessary.

Get ready to dive into the complex world of esophageal and gastroesophageal junction cancers! Discover the symptoms like dysphagia and hoarseness, and learn how to differentiate cancer types based on location. Uncover the risk factors for squamous versus adenocarcinoma. The discussion also covers the latest diagnostic techniques and staging criteria. Explore treatment options from endoscopic resection to cutting-edge chemotherapy regimens. Don't miss the insights on managing metastatic disease and key trials shaping future therapies!

Explore the world of Immune Thrombocytopenia Purpura (ITP) in this enlightening discussion. Learn about the mechanisms of antibody-mediated platelet destruction and the factors that can lead to this condition. Discover the clinical signs to watch for and the comprehensive diagnostic approach used by experts. The conversation dives into treatment options, from steroids to advanced therapies like TPO agonists and rituximab. It's a crucial update packed with insights relevant for heme consults and board reviews.

Dive into the intricate world of bone sarcomas as the hosts break down vital topics like diagnosis, staging, and treatment strategies. Explore the unique characteristics of osteosarcoma and Ewing's sarcoma, highlighting the importance of personalized therapies. Discover how genetic mutations influence treatment plans and the critical role of surgical interventions. With a focus on the latest chemotherapy protocols and emerging systemic treatments, this discussion sheds light on a challenging yet fascinating area of oncology.

Delve into the latest insights on soft tissue sarcomas, featuring new FDA approvals and evolving diagnostic challenges. Discover the complexities of this rare category of tumors, which represent just 1% of adult cancers and include both noncancerous and aggressive forms. Learn about treatment strategies for various subtypes, including desmoid tumors and Kaposi's sarcoma, highlighting innovative surgical and chemotherapy advancements. The emphasis is on a multidisciplinary approach to enhance patient outcomes.

Dive into the world of Thrombotic Thrombocytopenic Purpura (TTP) with high-yield facts on its mechanisms, symptoms, and treatment strategies. Explore the urgency of prompt diagnosis and how plasmapheresis can save lives. Learn about Hemolytic Uremic Syndrome (HUS), especially its impact on children and the critical need for early intervention. The discussion covers risk factors and treatment options, making it essential knowledge for both medical professionals and anyone interested in understanding these serious conditions.

This week dives deep into gastric adenocarcinoma, discussing risk factors like H. pylori infections and the importance of genetic testing. The latest staging techniques, including EGD and biopsies, are detailed for managing advanced cases. Advances in treatment are highlighted, with a focus on the newly approved zolbituximab for metastatic cases. The use of immunotherapy for specific genetic profiles is also explored, alongside ongoing clinical trial impacts and future directions in gastric cancer care.

Dive into a fascinating update on endometrial cancer featuring crucial insights on risk factors like Lynch syndrome. Explore the typical presentation, including postmenopausal bleeding, and learn about the diagnostic process through endometrial biopsy and FIGO staging. Discover surgical management options, adjuvant therapies, and cutting-edge molecular profiling techniques. The discussion also touches on rare uterine malignancies, providing a well-rounded overview of this critical topic.

Join oncologists Dr. Tom Powles and Dr. Brian Rini as they dive into the latest strategies for managing metastatic renal cell carcinoma. They discuss the importance of risk stratification and patient characteristics in treatment selection. The conversation covers the evolving role of cytoreductive nephrectomy, the significance of immunotherapy breaks, and the complexities of side effects from tyrosine kinase inhibitors. Listen for insights on tailored approaches for various RCC subtypes and career advice for budding oncologists!

Join renowned oncologists Tom Powles, a leading expert in GU oncology from Barts Cancer Center, and Brian Rini, a pioneer in clinical trials at Vanderbilt, as they delve into the latest insights on localized renal cell carcinoma. They explore critical risk factors, including smoking and genetic conditions like von Hippel-Lindau syndrome. The duo examines evolving treatment strategies, including nephrectomy, ablative techniques, and the emerging role of immune therapies, shedding light on their potential impacts on patient outcomes.