Two Onc Docs Endometrial (Uterine) Cancer 2025 UPDATE
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Aug 11, 2025 Dive into a fascinating update on endometrial cancer featuring crucial insights on risk factors like Lynch syndrome. Explore the typical presentation, including postmenopausal bleeding, and learn about the diagnostic process through endometrial biopsy and FIGO staging. Discover surgical management options, adjuvant therapies, and cutting-edge molecular profiling techniques. The discussion also touches on rare uterine malignancies, providing a well-rounded overview of this critical topic.
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Classic Presentation And Red Flags
- Postmenopausal vaginal bleeding is the hallmark presentation and should prompt endometrial biopsy.
- Ninety percent of endometrial cancers present with abnormal bleeding, but discharge, pelvic pain, or bowel changes also occur.
Assess Risk Factors And Lynch Prophylaxis
- Assess hormonal and genetic risk factors like obesity, tamoxifen use, PCOS, and Lynch syndrome.
- Offer prophylactic hysterectomy around age 35 for women with Lynch syndrome after childbearing is complete.
Biopsy And Staging Basics
- Use endometrial biopsy to confirm diagnosis and apply FIGO staging for treatment planning.
- Remember stage 1 confined to corpus, stage 2 cervical extension, and stage 3 regional spread.