Two Onc Docs Localized Kidney Cancer x Uromigos 2025 UPDATES (Part 1)
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Jul 28, 2025 
Join renowned oncologists Tom Powles, a leading expert in GU oncology from Barts Cancer Center, and Brian Rini, a pioneer in clinical trials at Vanderbilt, as they delve into the latest insights on localized renal cell carcinoma. They explore critical risk factors, including smoking and genetic conditions like von Hippel-Lindau syndrome. The duo examines evolving treatment strategies, including nephrectomy, ablative techniques, and the emerging role of immune therapies, shedding light on their potential impacts on patient outcomes.
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Scooter Story from Fellowship
- Tom Powles bought a children's scooter to commute during fellowship and quickly realized it gave the wrong professional impression.
- He advises fellows to consider transportation carefully in their first month to avoid such issues.
RCC Risk Factors Overview
- Most kidney cancer patients lack identifiable risk factors or inherited syndromes.
- Smoking is the most common but weak risk factor; inherited syndromes like Von Hippel-Lindau are rare but important.
Genetic Testing Indications in RCC
- Genetic testing for RCC is indicated in patients diagnosed under 46 or with bilateral or multifocal tumors.
- Know key syndromes like Birt-Hogg-Dubé, which have associated skin, lung, and kidney manifestations.