Two Onc Docs Localized Breast Cancer 2025 UPDATE
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Oct 13, 2025 Explore the latest in localized breast cancer treatments with 2025 updates! Discover when radiation can be skipped after surgery and the role of neoadjuvant therapies. Delve into the complexities of treating triple negative disease, including chemotherapy and the use of carboplatin. Understand hormonal therapies for ER/PR positive cases, their potential side effects, and the importance of genomic testing. Plus, insights on managing breast cancer in men and during pregnancy provide a comprehensive view of contemporary care options.
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Breast Cancer Receptor Breakdown
- About 70–80% of breast cancers are hormone receptor positive, 15–20% HER2 positive, and 15–20% triple negative. Stay current because practice evolves faster than board questions.
When To Omit Post-Lumpectomy Radiation
- Omit radiation after lumpectomy for women over 70 with tumors ≤2 cm, node negative, ER positive and give endocrine therapy. Trials are evaluating younger women but current guideline applies to >70.
Indications And Timing For Post-Mastectomy Radiation
- Add chest wall radiation after mastectomy for tumors >5 cm, close margins (<1 mm), node positive, or positive margins. Give radiation before systemic therapy at many centers to reduce radiation recall risk.