Two Onc Docs

Dive into the intriguing world of genetic syndromes that elevate cancer risk, particularly focusing on renal cell carcinoma. Learn about the critical roles of syndromes like von Hippel-Lindau and the promising drug Belzutafan. Discover how genetic mutations influence cancer risks and unique clinical manifestations. The discussion highlights the importance of early detection and intervention in conditions like Hereditary Leiomyomatosis. Plus, gain insights into germline testing for solid tumors and its impact on effective risk management.

Dive into the intriguing world of genetic syndromes linked to higher cancer risks. Discover how Li-Fraumeni syndrome and P53 gene mutations shape patient care. Uncover the critical implications of Lynch Syndrome and its ties to secondary cancers. Learn about familial adenomatous polyposis (FAP) and the importance of proactive screenings. Explore the roles of BRCA1 and BRCA2 genes in DNA repair and their significance in cancer management. This enlightening discussion emphasizes tailored strategies for better health outcomes.

Dr. Tom Powles and Dr. Brian Rini, experts in urologic oncology and renal cell carcinoma, delve into groundbreaking updates for metastatic kidney cancer. They discuss the IMDC classification and its role in risk assessment, emphasizing patient selection for treatments. Treatment strategies, including the balance between aggressive therapies and patient well-being, are explored. The duo also addresses challenges in non-clear cell variants and highlights the potential of emerging therapies. Finally, they share valuable advice for early-career oncologists, stressing the importance of mentorship.

Today’s episode we will cover 2024 updates for localized renal cell carcinoma (RCC). We will discuss risk factors, the presentation, staging, and treatment options. We are so excited to have Dr. Tom Powles and Dr. Brian Rini from the urologic oncology podcast Uromigos sharing their expertise on today's episode as well!

Dr. Larry Einhorn, a pioneer in testicular cancer treatment, shares his groundbreaking insights in the fight against non-seminomatous testicular cancer. He recounts the inspiring story of the first patient treated with platinum-based chemotherapy, showcasing the power of innovation. The discussion delves into effective management strategies, the importance of fertility preservation for patients, and the implications of the TIGER study comparing chemotherapy doses. Einhorn also offers invaluable advice for oncology trainees navigating their careers.

Dr. Larry Einhorn, a distinguished professor of medicine and a pioneer in the field of germ cell tumors, shares invaluable insights on testicular cancer. He discusses the significant advancements in treatment, particularly the introduction of platinum-based chemotherapy, which has dramatically improved cure rates. The conversation also covers the complexities of staging and managing seminomas, including the importance of tumor markers. Additionally, Dr. Einhorn emphasizes the need for proper education in medical training to better equip future professionals in tackling this disease.

Dive into the world of hematopoietic growth factors! Discover how G-CSF plays a crucial role in combating chemotherapy-induced neutropenic fevers. Learn about the complexities of dose-dense chemotherapy, particularly for breast and bladder cancers. Uncover strategies to manage chemotherapy-induced neutropenia and thrombocytopenia with thrombopoietin receptor agonists. Finally, explore the challenges of chemotherapy-induced anemia and the benefits of erythropoietin-stimulating agents, along with their potential risks.

Today marks our 2 year mark of Two Onc Docs! It’s been a while since we’ve done a re-intro so we figured we would re-introduce ourselves and explain why we picked heme/onc as a speciality, and briefly cover our study plans.

This podcast delves into cancer-related fatigue, discussing its definition, diagnosis, and management options. They explore coping strategies like exercise, therapy, and nutritional consultation. Additionally, they touch on treatment options such as steroids, herbal supplements, and psychostimulants for severe fatigue.

Dive into the world of Primary CNS Lymphoma as hosts unravel its impact on older and immunocompromised patients. Discover the complex symptoms and diagnostic challenges, especially in the elderly. Learn about advanced imaging techniques and the delicate balance of steroid use. The discussion moves into staging methods and cutting-edge treatments involving high-dose methotrexate and rituximab. Explore local therapies for patients unable to undergo systemic treatments and the critical timing needed for effective intervention.