Two Onc Docs

Dr. Tom Powles and Dr. Brian Rini discuss 2023 updates for localized bladder cancer, including diagnostic workup, staging, and treatment options. They share mixed opinions on a trial and challenges in therapy, express skepticism towards PET scans, and explore various treatment options. Exciting insights from the urologic oncology experts!

This podcast episode explores follicular lymphoma, discussing diagnostic criteria, treatment options, and the indolent nature of the disease. It also covers the importance of lymph node biopsy, staging criteria, and prognostication. Treatment criteria and options, including radiation and chemoimmunotherapy, are discussed. The role of maintenance CD20 antibodies, risk factors for transformation, and targeted regimens for relapse are also highlighted.

This podcast episode updates the treatment options for metastatic non-small cell lung cancer, including chemotherapy, immunotherapy, and targeted agents. It discusses various targetable mutations and their corresponding treatments, as well as the use of immunotherapy as a first and second line treatment. The chapter also explores the latest advancements in treating non-small cell lung cancer, including new trials and medications.

In this podcast, the hosts provide an update on the treatment landscape of early stage and locally advanced Non-Small Cell Lung Cancer (NSCLC). They cover topics such as pathology, staging, local and systemic therapy options, and special scenarios. The importance of understanding histological markers, diagnostic tests, and biomarker mutational testing is highlighted. They also discuss the classification and treatment options for NSCLC based on stage, including surgical options, SBRT, and perioperative treatment. Adjuvant chemotherapy regimens and controversies surrounding postoperative radiation are also addressed.

This podcast discusses testable thrombophilia syndromes including Antiphospholipid Syndrome, Antithrombin III deficiency, Protein C and S deficiency, Factor V Leiden, and Prothrombin mutations. They cover the presentation, diagnostic testing, and treatment, as well as the impact of medications on protein levels. Additionally, they explore the use of unfractionated heparin during C-sections, combination therapy for women with anti-phospholipid syndrome, and the timing of anticoagulation after delivery.

The podcast provides an update on metastatic breast cancer focusing on systemic therapy and toxicities. It discusses side effects of CDK46 inhibitors, dosing schedules, and second-line treatment options. Various chemotherapy options for metastatic breast cancer and approaches for HER2 positive and triple negative breast cancer are explored. The role of bone protective agents and the importance of clinical trials are also discussed.

Updates on radiation and therapies for localized breast cancer including adjuvant endocrine therapy. Systemic treatment options and importance of timely treatment. Treatment options based on hormone receptor, genomic status and significance of triple negative breast cancer. Genomic status, chemotherapy need, and side effects of medications. Treatment options for HER2 positive breast cancer including neo-adjuvant therapy.

This podcast provides high yield tips on breast cancer screening, prevention, and introduces non-invasive breast pathologies. It also discusses treatment options, including surgical procedures and lymph node staging. Key takeaways include screening recommendations, prevention strategies, and risk factors for breast cancer.

This podcast explores heparin induced thrombocytopenia, including its pathophysiology, diagnosis, and treatment. Topics include ruling out pseudo thrombocytopenia, understanding the role of heparin and Platelet Factor Four, diagnosing HIT using clinical criteria and additional testing methods, and the use of direct thrombin inhibitors for anticoagulation.

The podcast covers the different types of stem cell transplant, conditioning regimens, and complications. It discusses the use of stem cell transplantation in cancer treatment and finding donors for allogenic stem cell transplant. The importance of umbilical transplant and conditioning regimens is also highlighted. It further explores graft-versus-host disease and various complications that can occur in stem cell transplant patients.