Two Onc Docs

Dive into the world of hematopoietic growth factors! Discover how G-CSF plays a crucial role in combating chemotherapy-induced neutropenic fevers. Learn about the complexities of dose-dense chemotherapy, particularly for breast and bladder cancers. Uncover strategies to manage chemotherapy-induced neutropenia and thrombocytopenia with thrombopoietin receptor agonists. Finally, explore the challenges of chemotherapy-induced anemia and the benefits of erythropoietin-stimulating agents, along with their potential risks.

Today marks our 2 year mark of Two Onc Docs! It’s been a while since we’ve done a re-intro so we figured we would re-introduce ourselves and explain why we picked heme/onc as a speciality, and briefly cover our study plans.

This podcast delves into cancer-related fatigue, discussing its definition, diagnosis, and management options. They explore coping strategies like exercise, therapy, and nutritional consultation. Additionally, they touch on treatment options such as steroids, herbal supplements, and psychostimulants for severe fatigue.

Dive into the world of Primary CNS Lymphoma as hosts unravel its impact on older and immunocompromised patients. Discover the complex symptoms and diagnostic challenges, especially in the elderly. Learn about advanced imaging techniques and the delicate balance of steroid use. The discussion moves into staging methods and cutting-edge treatments involving high-dose methotrexate and rituximab. Explore local therapies for patients unable to undergo systemic treatments and the critical timing needed for effective intervention.

Explore the world of non-melanoma cutaneous malignancies such as squamous cell skin cancer and basal cell carcinoma. Get insight into staging, diagnosis, and treatment options, including the importance of thorough workups for suspicious lesions. Learn about high-risk skin cancers, treatment options for unresectable or metastatic cases, and the importance of complete tumor removal for basal cell carcinomas.

Exploring the diagnosis, risk factors, and demographics of malignant pleural mesothelioma. In-depth discussion on BAP1 gene mutation, cancer risks, screening recommendations, symptoms, and diagnostic process. Detailed explanation of staging pleural mesothelioma based on tumor size and lymph node involvement. Treatment strategies for stage 1-3 epithelioid pleural mesothelioma including induction chemotherapy and surgical procedures. Comprehensive treatment strategies for malignant mesothelioma tailored to different stages and histologies.

Exploring the vital role of Bone Modifying Agents like bisphosphonates and Denosumab in reducing skeletal complications for cancer patients. Discussing the impact of breast, prostate, and lung cancers on bone metastasis. Stressing the importance of creatinine clearance cutoffs, dental clearance, and monitoring for side effects prior to treatment. Highlighting the efficacy of these agents in managing metastatic diseases and rare bone sarcomas.

This podcast explores acquired causes of underproduction anemias, including iron deficiency, vitamin B12 and folate deficiencies, anemia of chronic disease, anemia of pregnancy, and rarer causes. It covers diagnostic methods, lab results, iron supplementation, micronutrient deficiencies, and treatment options.

This podcast focuses on cancers of unknown primary (CUP), discussing the work-up, diagnostic markers, molecular testing, and treatment options. They explore the use of immunohistochemistry and molecular testing for diagnosis and treatment, including specific markers for different types of cancer and the importance of identifying targetable mutations.

The podcast discusses the presentation, diagnosis, and treatment of Mantle Cell Lymphoma. They cover the workup, diagnostic criteria, and treatment options for both limited stage and advanced cases. They also explore various treatment options based on patient age and fitness, including stem cell transplant and agents for relapsed or refractory cases.