Two Onc Docs
Mantle Cell Lymphoma
Jan 29, 2024
The podcast discusses the presentation, diagnosis, and treatment of Mantle Cell Lymphoma. They cover the workup, diagnostic criteria, and treatment options for both limited stage and advanced cases. They also explore various treatment options based on patient age and fitness, including stem cell transplant and agents for relapsed or refractory cases.
09:41
AI Summary
AI Chapters
Episode notes
Podcast summary created with Snipd AI
Quick takeaways
- Mantle cell lymphoma can involve lymph nodes or external sites and has different prognostic features based on subtype.
- Treatment for mantle cell lymphoma depends on the stage, fitness, and age, with options including radiation, chemotherapy, stem cell transplant, and novel agents.
Deep dives
Overview of Mantle Cell Lymphoma
Mantle cell lymphoma is a type of mature B cell non-Hodgkin's lymphoma characterized by nuclear expression of cyclin D1 and translocation 1114. It can involve lymph nodes or external sites such as the blood, bone marrow, or GI tract. The usual presentation includes lymphadenopathy, spleenomegaly, and constitutional B symptoms. Diagnosis involves PET imaging, labs including tumor markers, and excisional biopsy. There are two major subtypes: classical mantle cell and non-nodal mantle cell, each having different prognostic features and expression of CD markers.
