Two Onc Docs
Cancers of Unknown Primary (CUP)
Feb 5, 2024
This podcast focuses on cancers of unknown primary (CUP), discussing the work-up, diagnostic markers, molecular testing, and treatment options. They explore the use of immunohistochemistry and molecular testing for diagnosis and treatment, including specific markers for different types of cancer and the importance of identifying targetable mutations.
10:07
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Quick takeaways
- A comprehensive workup and evaluation, including thorough history, physical examination, and imaging techniques, are crucial in identifying potential primary sites for cancers of unknown primary (CUP).
- Immunohistochemistry (IHC) staining and molecular testing play a vital role in diagnosing and determining the tissue of origin for CUP, with specific stains and markers helping differentiate between tumor types and guide personalized chemotherapy regimens.
Deep dives
Workup and Evaluation of Cancers of Unknown Primary
In this podcast episode, the hosts discuss the importance of a comprehensive workup and evaluation for cancers of unknown primary (CUP). They highlight the significance of conducting a thorough history and physical examination, including breast exams, testicular exams, pelvic exams, and skin exams. Additionally, imaging techniques such as CT scans and PET scans are essential in detecting primary lesions. The hosts emphasize the relevance of specific tumor markers, such as beta HCG, AFP, and PSA, in suggesting the origin of the tumor. They also explain the role of various tests, including mammograms, endoscopies, and scoping, in identifying potential primary sites for CUP.
