Two Onc Docs
Hematology for the IM Board Tips 2024
Jul 29, 2024
Get ready to ace your hematology questions! Explore essential insights on disorders like aplastic anemia and the intricacies of multiple myeloma diagnosis and management. Delve into myelodysplastic syndrome with a case study that highlights crucial testing. Learn about vitamin B12 deficiency and management strategies for acute promyelocytic leukemia. Finally, unpack bleeding disorders and the critical aspects of transfusion reactions, all with practical tips for your upcoming boards!
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Quick takeaways
- Understanding the treatment protocols for aplastic anemia and PNH is essential for addressing relevant board exam vignettes.
- Awareness of multiple myeloma diagnosis criteria and the implications of MGUS progression is crucial for effective patient management.
Deep dives
Key Concepts in Aplastic Anemia and PNH
Aplastic anemia and paroxysmal nocturnal hemoglobinuria (PNH) are highlighted as crucial subjects for internal medicine boards. A classic vignette presents a 64-year-old male with pancytopenia, indicating that the preferred treatment for aplastic anemia in patients over 50 is a combination of cyclosporine, horse ATG, and prednisone. For younger patients with a suitable HLA-matched donor, an allogeneic stem cell transplant is recommended. PNH diagnosis is established through flow cytometry, and treatment involves echoluzumab, alongside necessary meningococcal vaccinations before administration.
