

Bryan Johnson Podcast
Bryan Johnson
The Bryan Johnson Podcast is ushering in a new era of being human. In this podcast I am joined by longevity physician Dr. Mike Mallin, my co-founder Kate Tolo, and the occasional guest. We discuss the science-based protocol to help you become your best self.After living in Ecuador for two years among extreme poverty at the age of 21, I returned to the US and devoted my life to making the largest and most meaningful impact on humanity. After selling my company Braintree Venmo for $800 million, I traveled back in time to my 21 year old dreams of doing something impactful for the human race. I wondered if we may be the first generation to not die. I put together a team of 30 medical professionals and built the world’s best health protocol, Blueprint. On this protocol, I became the most biologically measured person in history and achieved the best biomarkers in the world, quantitatively becoming the healthiest person on the planet. Now is the first time in 2,000 years that a new, globally adopted ideology must emerge. AI is progressing faster than any of us can comprehend, causing us to reexamine everything we think about ourselves, each other, and society. This is now humanity’s to-do list: Don’t die individually. Don’t kill each other. Don’t destroy the planet. Align AI with Don’t Die.Join us on this journey. New episodes releasing weekly.
Episodes
Mentioned books

13 snips
Jun 22, 2025 • 54min
Evening Exercise, Poor Sleep, and Resting Heart Rate
Explore the controversial topic of evening exercise and its surprising impact on sleep quality. A new study reveals how late workouts can elevate resting heart rates and disrupt sleep. Learn why resting heart rate might be the ultimate biomarker for health and longevity, along with tips to lower it through lifestyle changes. The discussion also challenges the norm around alcohol consumption and its effects on heart health, rethinking social rituals that prioritize indulgence over genuine connection.

Jun 21, 2025 • 31min
India's Air Pollution and Hyperbaric Oxygen Therapy
There’s a new treatment for longevity — one you probably haven’t heard of before. I review my experiments with hyperbaric oxygen therapy (HBOT) and how it dramatically transformed my biomarkers. We’ll also cover the ways air pollution shows up in your body, something I experienced firsthand while traveling in India.
Links and Studies
Analyzing India’s Air Quality: https://x.com/bryan_johnson/status/1863474991142236217
https://x.com/bryan_johnson/status/1864091348179222955
Bryan’s HBOT protocol + results:
https://x.com/bryan_johnson/status/1861085751024484459
https://x.com/bryan_johnson/status/1902044120807567436
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
0:00 - Intro
1:02 - Hyperbaric Oxygen Therapy (Bryan's Results)
15:37 - India's Air Pollution
23:58 - Air Quality Protocol
29:49 - Have A Plan

Jun 20, 2025 • 37min
Creatine, Sleep Trackers, and AI Doctors
What’s the truth when it comes to creatine? And which sleep tracker gets you the best results? Blueprint co-founder Kate Tolo and Blueprint Chief Medical Officer Dr. Mike Mallin join me to discuss the science behind some of the hottest wellness topics to find out which ones are actually worth your time.
UNSW Creatine study: https://www.unsw.edu.au/newsroom/news/2025/03/sports-supplement-creatine-makes-no-difference-to-muscle-gains-trial-finds
Andrej Karpathy’s sleep tracker study: https://karpathy.bearblog.dev/finding-the-best-sleep-tracker/
Connect:
X: https://x.com/bryan_johnson
YouTube: https://www.youtube.com/@BryanJohnson
Instagram: https://www.instagram.com/bryanjohnson
TikTok: https://www.tiktok.com/@_bryan_johnson_
Chapters
0:00 - Intro
0:41 - 1: Welcome to the Don't Die podcast
2:52 - 2: Dr. Mike’s experience as an ER physician
7:32 - 3: Difference between America and New Zealand ER
9:38 - 4: Dr. Mike on using ChatGPT
13:00 - 5: New study on creatine effectiveness
18:40 - 6: How much creatine to take per day
24:33 - 7: Body awareness
29:33 - 8: Blueprint protocol’s limit in slowing aging
30:57 - 9: Andrej Karpathy’s sleep monitor study
36:10 - Conclusion

Jun 19, 2025 • 27min
Fixing Trevor Wallace's Burnout Lifestyle
Trevor Wallace, a witty comedian and host of 'Stiff Socks,' dives into the chaos of life on the road. He shares his struggles with convenience foods, emphasizing how they’ve impacted his health. The conversation shifts to practical health tips, including the importance of a bedtime routine and the benefits of sleep for creativity. Trevor's experiences highlight the difference between his biological and chronological age, prompting a humorous reflection on personal wellness. Expect laughs mixed with some surprising health insights!

Jun 19, 2025 • 1min
This is the Bryan Johnson Podcast
Join a lively discussion about health, aging, and the quest for immortality. The hosts share personal stories and hilarious insights about wellness and the challenges of growing older. With a focus on science-based strategies, they explore societal views on male health and what it truly means to be your best self. Expect humor and camaraderie as they navigate these complex topics with a lighthearted approach.

Jun 19, 2025 • 1h 42min
The Future of Fitness: Dr. Mike Israetel on AI, Steroids & Online Criticism
Fitness expert Dr. Mike Israetel, a competitive bodybuilder and co-founder of Renaissance Periodization, shares insights on the intersection of AI and fitness. He discusses the complexities of steroid use, outlining the risks and considerations for young aspirants. Mike opens up about handling online fame and criticism, emphasizing the importance of integrity in the fitness world. Their conversation also includes lighthearted stories of arm wrestling and the balance between longevity and enjoying life, making for an engaging and informative discussion.