The Energy Blueprint Podcast

Dr. Mariza Snyder, a functional medicine practitioner and author of The Perimenopause Revolution, dives deep into the challenges of perimenopause. She uncovers the FDA's recent removal of the HRT warning and discusses the vital role of estrogen in brain health. Dr. Snyder highlights the 'window of vulnerability' women face during this transition, revealing that 84% don’t seek help due to feeling judged. Her book serves as a roadmap for understanding symptoms and finding practical solutions, emphasizing the need for better women's health care and support.

In this episode with Dr. John Lieurance, he drops a bombshell in the first few minutes: "I take hundreds of milligrams [of melatonin] every night, and I've gone through months and months of taking it religiously." While most melatonin supplements contain a dose of 0.3 to 3 milligrams, Dr. Lieurance has 30 years of clinical experience and, during our conversation, shares his unorthodox but largely research-backed views on melatonin, methylene blue, and mitochondrial health. As one of the world's leading clinical experts on melatonin and methylene blue, Dr. Lieurance reveals findings that most people have never heard, including why melatonin is an amazing adaptogen and how it even prevents the Warburg effect that powers cancer cells. The second half of our conversation explores methylene blue, the original compound that inspired the term "magic bullet." Dr. Lieurance explains how this brilliant blue salt was discovered while searching for a malaria cure, how it increases mitochondrial function by an average of 30%, and why it acts as both a prooxidant and antioxidant. Most fascinating is the synergy with red light therapy…methylene blue absorbs 660-nanometer photons, supports cytochrome C oxidase, and creates powerful antimicrobial effects. He shares clinical dosing protocols, debunks FDA warnings, and explains why higher doses are more effective than the micro-doses commonly recommended. In this podcast, Dr. Lieurance and I discuss: His personal health journey and why he takes hundreds of milligrams of melatonin every night, while maintaining high testosterone levels, directly contradicting Andrew Huberman's warnings based on flawed rodent studies Melatonin studies that used up to 150,000 milligrams with zero toxicity found, yet recent claims suggest melatonin is toxic to kids, with little research to support it The fact that your gut produces 400 times more melatonin than the pineal gland! Every single cell produces its own melatonin within the mitochondria, a discovery that only emerged in the last couple years, completely reframing melatonin's importance The biological reason why you can take large amounts of melatonin for extended periods and stop the next day without suppression of natural production The connection between melatonin, hormesis, and your mitochondria How high-dose melatonin protects you from sun damage The interesting story of methylene blue, the original "magic bullet" discovered while curing malaria How methylene blue increases mitochondrial function by 30% on average

In this conversation, Dr. Chris Masterjohn, a nutrition scientist and PhD expert in micronutrients, unpacks the essential foods for mitochondrial health. He debunks supplement myths, revealing your mitochondria need more than CoQ10. Learn how your brain signals regulate energy and why post-meal fatigue might be linked to toxic metabolites. Dr. Masterjohn shares his go-to superfood cocktail and discusses the crucial micronutrients like B vitamins and magnesium, all vital for optimizing energy and combating fatigue!

What if curing cancer and heart disease wouldn't actually extend human lifespan by much? It sounds crazy, but this concept opens the door to my conversation with Dr. Greg Kelly, Director of Product Development at Neurohacker Collective and author of Shape Shift. The reason is simpler than you think: most people would still die in their mid-80s from accumulated cellular damage and "dying of old age," i.e., multi-organ failure from decades of cellular aging. Dr. Kelly brings a unique perspective, having served as a Navy officer before becoming a naturopathic physician and spending two decades in the trenches of longevity research. He shares a fascinating personal story about repaying his massive sleep debt from his military years—sleeping 12 hours a night for weeks until his chronically cold hands suddenly became warm. His insights on why catching up on sleep often makes us feel more tired will completely reframe how you think about recovery. This conversation goes deep into cellular senescence ("zombie cells" that accumulate as we age), the gut microbiome's role in longevity, why melatonin supplements are often misused, and which nootropics actually work. Dr. Kelly explains the "last straw" model of stress that will change how you view your health, and why chasing individual diseases instead of focusing on cellular aging is like rearranging deck chairs on the Titanic. This episode was initially released in July 2023

Dr. Dale Bredesen, expert in preventing and reversing cognitive decline, discusses root causes of cognitive decline, downsizing network, link between cognitive demands and Alzheimer's, relationship between fruit consumption and cognitive decline, role of ketosis in a ketogenic diet, relationship between vascular issues and dementia, and efficacy of drug treatments for Alzheimer's.

Dr. Eric D. Gordon, with over 40 years of experience, discusses the history of alternative medicine, major aspects of health missed by functional medicine, the real reason behind chronic fatigue, and the intelligence of the body. They explore the concept of sickness behavior, the need for a systems approach in understanding human biology, and the role of mitochondria in the cell danger response. The power of the mind in healing and finding joy for health and wellbeing is also emphasized.

Dr. Eric Balcavage, a thyroid health expert and author of The Thyroid Debacle, shares insights on a mitochondria-centric approach to thyroid health. He discusses why immune-driven thyroiditis is often overemphasized and how mitochondria influence our metabolic priorities. Eric critiques the common hormone-first treatments, warning they may worsen symptoms rather than help. He introduces the idea of viewing symptoms as intelligent adaptations and outlines practical steps to enhance health, including prioritizing a whole-food diet and improving sleep.

Rome Za, a movement specialist and founder of the Rome Za method, talks about his intense childhood, the key factor for nervous system healing, recurring issues in coaching clients, 2 nervous system assaults, non-traditional strength movements, and 3 core insights for a steady nervous system.

Dr. Gabrielle Lyon, a physician in nutritional science and geriatrics, discusses the link between muscle health and longevity, emphasizing the role of muscle as the organ of longevity. Topics covered include the decline in mitochondrial capacity with age, strategies for improving muscle health and mitochondrial function, relationship between climate, appetite, and body composition, protein absorption, and debunking claims about high protein consumption promoting cancer. Key recommendations include physical exercise and dietary interventions for promoting muscle and mitochondrial health.

In this engaging conversation, Dr. Aimie Apigian, a double board-certified physician and author of The Biology of Trauma, reveals trauma's biological roots beyond just psychological aspects. She discusses how trauma encodes itself in our cells and nervous system, and introduces her innovative safety-first method to healing. Aimie explains the critical role of mitochondria, the interplay of oxidative stress, and how high-functioning individuals adapt to trauma. Her insights challenge traditional views, emphasizing a comprehensive mind-body approach to recovery.