View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter’s Weekly Newsletter Stephan Guyenet is a neuroscientist focused on the neuroscience of obesity and energy homeostasis.  He is the author of the book, The Hungry Brain and founder/director of Red Pen Reviews. In this episode, Stephan explains how obesity has changed phenotypically over the course of human history as well as what might explain the dramatic increase in prevalence of obesity in the last few decades. He talks in depth about the role of genetics, the brain, and hormones like leptin play in the regulation of fat mass. He dives deep into two common theories of obesity—the carbohydrate-insulin model and the energy balance model and provides his take on which theory has stronger evidence. Additionally, he provides insights on how we’re hard-wired to think about food and the consequences of modern foods designed for maximal pleasure. Finally, he goes through the factors that affect body weight, set points, and provides takeaways for people wanting to take advantage of what we know about the brain’s role in regulating our body weight. We discuss: Stephan’s neuroscience background and his focus on the nuances of obesity [2:15]; How obesity has changed for humans throughout history [8:00]; The association between obesity and adverse health outcomes, the “obesity paradox,” and confounders when relating BMI to longevity [14:00]; The sharp increase in obesity across demographics [23:30]; The hypothalamus and its role in obesity [30:00];  The role of the hormone leptin in obesity [40:00]; The genetic component of obesity [46:30]; Understanding the tendency of humans to store fat through an evolutionary lens [57:00];   The hedonic aspect of food, and how the brain reacts to modern, highly-rewarding foods [1:03:30]; How we are hard-wired to think about food [1:14:30]; A review of the “Carnivore diet” [1:21:45]; The energy balance model, carbohydrate-insulin model, and unifying the theories around adiposity [1:34:15]; Body weight set points: a hypothetical comparison of two individuals [1:41:45]; Takeaways for people who want to lose weight and keep it off [1:48:30]; Evidence that favors the energy balance model of weight gain [1:56:00]; The synergistic effect of fat and carbohydrates and observations that a low-fat diet or a low-carb diet can cause weight loss [2:04:30]; Red Pen Reviews [2:11:00]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Dr. Stephan Guyenet, an expert in obesity neuroscience and eating behavior, dives into the complexities of appetite regulation and metabolism. He discusses how liposuction affects leptin levels and hunger, along with long-term impacts of crash diets on appetite. Fascinatingly, he explores the concept of the 'brain microbiome' and its potential role in obesity. Guyenet also critiques weight management strategies, suggesting that drugs and bariatric surgery may be essential in today's environment, while emphasizing the need for a sustainable approach to health.

Episode #260. Are you struggling to maintain a healthy weight and navigate the confusing world of diets and weight loss solutions? In this episode, join me as I dive into the science behind eating behaviours, obesity, and the challenges of losing weight with renowned researcher Dr Stephan Guyenet.Discover the different types of eating, the importance of controlling our food environment, and various evidence-based strategies for weight loss. With practical advice and insights from Dr Guyenet, you'll gain a better understanding of the complexities of weight management and how to make informed choices for your health. Don't miss this eye-opening conversation about the widespread issue of obesity and our brain's role in eating behaviours.Specifically, we discuss: Intro (00:00) From neurodegenerative disease to obesity neuroscience (01:36) The holiday weight gain (10:38) The problem with excess fat (14:37) 'Personal fat threshold' and diabetes (26:06) Main drivers of type 2 diabetes (31:26) The role of the hypothalamus in weight gain (38:55) Homeostatic vs. non-homeostatic eating (47:29) Genetics and the obesity epidemic (56:50) Models of obesity: carbohydrate -insulin vs. energy balance (1:00:21) The brain and obesity (1:10:34) The protein-leverage hypothesis (1:19:39) Carbohydrates, fat, and the Mediterranean diet (1:24:08) The weight loss puzzle: low carb vs. low fat diet (1:30:10) Foods that promote satiety on fewer calories (1:38:25) GLP-1 agonists (1:43:08) Is weight loss largely dependent on exercise? (1:55:06) Physical activity vs sedentary lifestyle (1:58:40) Mental health and sleep (2:00:28) Expert advice on how to stop overeating (2:05:11) Outro (2:05:59) To connect with Dr Stephan Guyenet, you can find him on Twitter or visit his website, https://www.stephanguyenet.com/. You can also purchase Dr Guyenet’s widely acclaimed book, The Hungry Brain, to learn more about why we overeat and how to overcome this issue. Make sure to also check out Red Pen Reviews, where you can access free expert reviews on nutrition books.Discover more insights and supporting resources in the full show notes.Enjoy, friends.SimonWant to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary two-week meal plan and high protein Plant Performance recipe book

Stephan Guyenet, PhD, discusses overeating, appetite regulation, calorie balance, neuroscience, African Rift Valley, Hodza people's sugar intake, factors contributing to obesity, practicality of dieting, effects of marijuana on appetite.

Neurobiologist and obesity researcher Dr. Stephan Guyenet discusses how the brain regulates body fatness, the difference between hunger and cravings, why we eat, and the benefits of GLP-1 medicines.

Noted researcher Stephan Guyenet discusses contributors to weight gain, genetic influences, and ultra-processed foods. They also talk about the new weight management drug semaglutide, a brief history of the pharmaceutical management of obesity, and Stephan Guyenet's Red Pen Reviews.

Stephan Guyenet, PhD discusses fat mass regulation via energy homeostasis systems, overeating, and the difference between homeostatic and non-homeostatic eating. They explore the interplay between satiety, energy homeostasis, and hedonic systems in regulating food intake. They discuss the challenges of weight maintenance and strategies for weight loss, including metabolic adaptations and controlling the food environment.

Dr. Stephan Guyenet, an obesity researcher, discusses the brain's role in body fatness, genetics vs. environment in obesity risk, stress and emotional eating impact, challenges of sustained fat loss, tips for healthy body composition maintenance, and navigating 'treat meals' without hindering progress.

Neurodegenerative disease and obesity neuroscience expert, Stephan Guyenet, PhD, answers questions on the impact of liposuction on hunger, effects of chronic energy restriction on appetite hormones, dysregulation versus normal regulation of body mass, and the benefits of Sigma Nutrition Premium.

Nutrition researchers Dr. Guyenet and Dr. Kratz discuss conflicting diet claims, including Carnivore Code and The Plant Paradox. They debate the health benefits and risks of the carnivore diet, the impact of LDL on cardiovascular health, and the validity of nutritional claims. Red Pen Reviews provides unbiased evaluations of nutrition books to combat misinformation.