Sigma Nutrition Radio #537: Appetite Regulation, Metabolic Compensation and More – Stephan Guyenet, PhD
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Oct 1, 2024 
Dr. Stephan Guyenet, an expert in obesity neuroscience and eating behavior, dives into the complexities of appetite regulation and metabolism. He discusses how liposuction affects leptin levels and hunger, along with long-term impacts of crash diets on appetite. Fascinatingly, he explores the concept of the 'brain microbiome' and its potential role in obesity. Guyenet also critiques weight management strategies, suggesting that drugs and bariatric surgery may be essential in today's environment, while emphasizing the need for a sustainable approach to health.
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Liposuction's Impact on Leptin & Fat
- Liposuction reduces subcutaneous fat but has variable effects on leptin levels.
- The body tends to regain fat, defending a baseline fat mass set point.
Appetite Drives Fat Regain After Dieting
- Chronic energy restriction triggers a regulatory system increasing appetite to restore lost fat.
- This regulatory response is normal, not evidence of long-term appetite dysregulation.
Genetics and Body Fat Set Points
- Obesity reflects a higher defended body fat set point, not a failure of the regulatory system.
- Anorexia and obesity have strong genetic components influencing body fat regulation.