This is an “ask me anything” (AMA) episode with Dr. Stephan Guyenet, an expert in obesity neuroscience and eating behavior. This episode was originally published on Sigma Nutrition Premium. If you’re interested in subscribing to Sigma Nutrition Premium, then check all the details here.

1. [04.27] If we surgically remove adipose tissue, do leptin levels suddenly drop? How would this impact hunger over time?
2. [06.56] How does chronic energy restriction (or following a crash diet) affect long-term appetite regulation?
3. [13.21] How do anorexia and pronounced obesity defy the rules of metabolic compensation?
4. [24.12] Why do some SDRIs (serotonin–dopamine reuptake inhibitors) reduce hunger/appetite?
5. [28.02] Can an algorithm really decipher someone’s “ideal weight?
6. [33.08] Could the “brain microbiome” impact appetite regulation and/or obesity?
7. [35.34] In our current environment, are the only efficacious interventions drugs and bariatric surgery?
8. [46.01] What should we make of claims by Gary Taubes about insulinogenic foods?
9. [52.37] Is there a maximum duration someone should spend in fat loss (or weight gain) phases?
10. [53.43] Why do some people struggle to gain weight?

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