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Sigma Nutrition Radio

SNP7: Stephan Guyenet, PhD - Ask Me Anything!

Jul 19, 2022
Neurodegenerative disease and obesity neuroscience expert, Stephan Guyenet, PhD, answers questions on the impact of liposuction on hunger, effects of chronic energy restriction on appetite hormones, dysregulation versus normal regulation of body mass, and the benefits of Sigma Nutrition Premium.
16:43

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • Liposuction may initially reduce leptin levels but fat regain occurs due to homeostatic reaction, making it ineffective for long-term fat loss.
  • Chronic energy restriction and crash dieting activate a regulatory system in the brain opposing fat loss, increasing eating drive and potentially reducing energy expenditure.

Deep dives

Impact of Liposuction on Leptin Levels and Fat Regain

Studies show variable impact on leptin levels up to 6 months post liposuction. However, fat regain consistently occurs due to a homeostatic reaction. Liposuction still provides aesthetic benefits by redistributing fat mass, but it is not effective for long-term reduction of fat mass.

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