If you think you really understand Alzheimer's, think again! Alzheimer’s is scary to witness up close and personal and even scarier when you consider that anyone who’s had Covid-19 is at an increased risk for developing Alzheimer’s! An astounding 45 million people currently living in America will die with Alzheimer’s disease and according to Dr Dale Bredesen, this number dwarfs the high rates of death we just experienced with Covid-19, it’s just a slower process.This special episode is a panel discussion with two of the world’s leading experts on Alzheimer’s, Dr. Dale Bredesen and Dr. Richard Johnson.Dr. Bredesen is an international neurodegenerative expert and the author of, The First Survivors of Alzheimers, a book that spotlights first person accounts of his patients that not only survived Alzheimers, but who got back a second life to live with meaning and fulfillment.Dr. Richard Johnson, the fructose expert, wrote the book, Nature Wants Us To Be Fat. His focus and research points to the connection between Alzheimer’s disease and sugar.This conversation between experts is enlightening and has a few points you’ll want to take note of to further discuss with your healthcare professional. Dr. Bredesen reveals why a complete assessment of your brain, blood levels and more needs to be completed as early as 40 years old to start taking preventative measures to protect yourself from Alzheimer’s.Alzheimer’s has been referred to as type 3 diabetes and both experts agree that this disease is an insulin resistant state of the brain. What can you start doing today to lower your risks and the risks of the people you love? FOLLOW Dr. Dale Bredesen:Website: https://www.apollohealthco.com/dr-bredesen/ LinkedIn:https://www.linkedin.com/in/dale-bredesen-2ab0651/ Facebook: https://www.facebook.com/drdalebredesen/Follow Richard Johnson: Website: https://drrichardjohnson.com/ Instagram: https://www.instagram.com/drrichardjjohnson/ SPONSORS:This episode is sponsored by BetterHelp. Give online therapy a try at https://bit.ly/BetterhelpImpact and get on your way to being your best self.Head over to https://bit.ly/AnthrosImpact and get $200 off the office chair that promises to be the world's most comfortable sitting experience.Get 5 free AG1 Travel Packs and a FREE 1 year supply of Vitamin D with your first purchase at https://bit.ly/AG1Impact.No interest, no payments - take advantage of this special financing offer at https://bit.ly/NetsuiteImpact to get the visibility and control you need to weather any storm.Sign up today at https://bit.ly/ButcherBoxImpact and use code IMPACT to get a FREE TURKEY ​plus $20 off your first order.​Are You Ready for EXTRA Impact?If you’re ready to find true fulfillment, strengthen your focus, and ignite your true potential, the Impact Theory subscription was created just for you.This is not for the faint of heart. This is for those who dare to learn obsessively, every day, day after day.Subscription Benefits: Unlock the gates to a treasure trove of wisdom from inspiring guests like Andrew Huberman, Mel Robbins, Hal Elrod, Matthew McConaughey, and many, many, more New episodes delivered ad-free Exclusive access to Tom’s AMAs, keynote speeches, and suggestions from his personal reading list You’ll also get access to an 5 additional podcasts with hundreds of archived Impact Theory episodes, meticulously curated into themed playlists covering health, mindset, business, relationships, and more: Legendary Mindset: Mindset & Self-Improvement Money Mindset: Business & Finance Relationship Theory: Relationships Health Theory: Mental & Physical Health Power Ups: Weekly Doses of Short Motivational Quotes  Subscribe on Apple Podcasts: https://apple.co/3PCvJazSubscribe on all other platforms (Google Podcasts, Spotify, Castro, Downcast, Overcast, Pocket Casts, Podcast Addict, Podcast Republic, Podkicker, and more) : https://impacttheorynetwork.supercast.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode is brought to you by InsideTracker.Why do we get fat? As Americans have gotten heavier over the past century, and disease rates have skyrocketed, there have been many theories: We’re eating too much fat. Too many carbs. An excess of sugar. Is it our lifestyle or our diet that’s to blame? Or could there be a single common cause that explains the sharp increase in not only obesity, but conditions as disparate as heart disease, cancer, and dementia? This week on The Dhru Purohit Podcast, Dhru sat down with Dr. Richard Johnson to talk about his team’s discovery of the fructose-powered survival switch—a metabolic pathway that animals in nature turn on and off as needed, but that our modern diet has permanently fixed in the on position, becoming a fat switch—and how it has revolutionized the way we think about why we gain weight. Dr. Richard Johnson is a Professor of Medicine at the University of Colorado in Denver and has been a practicing physician and clinical scientist for over 25 years. He is internationally recognized for his seminal work on the role of sugar and its component fructose, in obesity and diabetes. His work has also suggested a fundamental role for uric acid (which is generated during fructose metabolism) in metabolic syndrome. His new book is entitled Nature Wants Us to Be Fat and will be published on February 8, 2022.In this episode, we dive into: -Why nature wants us to get fat and why it’s important for survival (5:44)-What triggers the fat storage switch (9:05)-The central function of uric acid in the body (16:32)-How uric acid, previously thought of only in terms of gout, is actually playing a central role in metabolic disorders (20:54)-Understanding the difference between fructose and glucose (26:12)-Why obesity is not a calories in, calories out problem (29:38)-Why it’s fructose (not glucose) that drives insulin resistance and metabolic disease (49:51)-The survival switch: why humans become fat (1:10:38)-Alcohol consumption and obesity (1:33:54) -The surprising role salt and dehydration play in fat accumulation (1:48:45) Also mentioned in this episode:-Nature Wants Us to Be Fat: The Surprising Science Behind Why We Gain Weight and How We Can Prevent—and Reverse—It - https://benbellabooks.com/shop/nature-wants-us-to-be-fat/.For more on Dhru Purohit, follow him on Instagram @dhrupurohit, and on YouTube @dhrupurohit. You can also text Dhru at (302) 200-5643.This episode is brought to you by InsideTracker.InsideTracker looks at everything from metabolic and inflammatory markers to nutrients and hormones. Traditional lab tests can be hard to read on your own, but InsideTracker makes their results easy to understand and provides tips on how to use food first for optimal nutrition. Right now, they’re offering my podcast community 25% off. Just go to insidetracker.com/DHRU. Hosted on Acast. See acast.com/privacy for more information. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this engaging discussion, Dr. Richard Johnson, a seasoned physician and medical scientist, unveils intriguing insights into weight gain and insulin resistance. He discusses the surprising connection between the sweetener Alulose and metabolic health, revealing its potential in diabetes management. Delving into carbohydrate effects, he highlights how fructose impacts cellular energy and its ties to Alzheimer's. Dr. Johnson also shares exciting developments in mitochondrial health and dietary strategies that could combat cognitive decline.

Fructose and its byproduct uric acid may play a role in the development of Alzheimer’s, thanks to an evolutionary adaptation hijacked by the modern diet. Fructose can be directly consumed, or the body can convert high-glycemic carbohydrates and other foods to fructose. Fructose suppresses some cognitive functions. Dr. Richard Johnson and Dr. Rob Lustig discuss a new study, of which Johnson was an author, on how fructose may be a potential driver in Alzheimer’s, and they hypothesize about fructose’s potential connection to the development of other conditions. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl 🎙 What Richard Johnson, MD, & Rob Lustig, MD, discuss: (09:50) — Fructose is the driver of some diseases that are on the rise in kids (11:53) — Fructose is a driver of obesity and metabolic syndrome (15:36) — Pharmaceutical treatments for Alzheimer’s disease aren’t as effective as researchers had hoped (17:32)— The research focus of Alzheimer’s is slowly shifting to understanding insulin resistance in the brain (20:41) — Is fructose a root cause of Alzheimer’s? (26:26) — New research suggests fructose induces a foraging response (28:20) — Fructose inhibits areas of the brain to encourage successful foraging (46:48) — We need more research on fructose (1:03:10) —Is fructose a factor in violence? Transcripts & Show notes Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 👋 WHO WE ARE: Levels helps you see how food affects your health. With real-time, personalized data gathered through biosensors like continuous glucose monitors (CGM), you learn which diet and lifestyle choices improve your metabolic health so you can live a longer, fuller, healthier life. 🔗 LINKS: Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?: https://www.sciencedirect.com/science/article/abs/pii/S0002916523000047?dgcid=author Subscribe here on YouTube: https://youtube.com/levelshealth?sub_confirmation=1 📲 CONNECT: Connect with Richard Johnson, MD, on Instagram: https://www.instagram.com/drrichardjjohnson/ Connect with Robert Lustig, MD, on Instagram: https://www.instagram.com/robertlustigmd/

In this insightful discussion, Dr. Richard Johnson and Dr. Robert Lustig delve into the hidden dangers of sugar, revealing how it disrupts metabolism and contributes to weight gain. They equate sugar addiction to alcohol addiction and emphasize the alarming rise in sugar consumption's impact on mental health. With practical detox strategies, they advocate for recognizing hidden sugars and improving food quality. The duo highlights the benefits of cutting sugar from your diet, which can alleviate chronic stress and inflammation.

Dr. Richard Johnson and Dr. Rob Lustig discuss how fructose could be a driver of Alzheimer's disease. They explore fructose's impact on obesity, metabolic syndrome, and cognitive functions, suggesting a potential connection to other conditions. The podcast delves into new research on fructose inducing a foraging response in the brain and its inhibitory effects, raising the question of fructose's role in various health issues beyond Alzheimer's.

Dr. Casey Means and Dr. Richard Johnson discuss the survival switch that drives our body to store fat, the impact of sugar on metabolic syndrome, fructose's depletion of energy, the protective role of vitamin C against obesity, and how salt can trigger fructose production.

Dr. Richard Johnson is a professor of medicine at the University of Colorado, and is a clinician, educator, and researcher. For more than 20 years, he has led research on the cause of obesity and diabetes, with special interest in the role of sugar (especially fructose) and uric acid. His latest book, Nature Wants Us to Be Fat: The Surprising Science Behind Why We Gain Weight and How We Can Prevent—and Reverse—It, is out now. Become a Genius Life Premium Member and get ad-free episodes of the show, a monthly Ask Me Anything (AMA), and more! Learn more: http://thegeniuslife.com

To bring in the new year I thought it would be good to take a moment and consolidate some of the memorable moments, and key takeaways, from 2022. In Episode #241, part 1 of a 2 part year in review, we traverse how to think about nutrition, so we can better make sense of claims online, diet, and cardiometabolic health, how you can flip the switch on your microbiome so the trillions of gut bugs in your large intestine reward you with better health, and the benefits up for grabs through consuming our food over less hours - otherwise known as time restricted eating or fasting.Guests featured include Dr Gil Carvhalo, Dr Richard Johnson, Dr Alan Flanagan, Danny Lennon, Dr David Jenkins, Dr Justin Sonnenburg, Dr Erica Sonnenburg, Dr Christopher Gardner, Dr Tim Spector, Dr Don Layman, Dr Valter Longo, Dr Stuart Phillips, Dr Satchin Panda and Dr Courtney Peterson.Specifically, we cover: Intro (00:00) Circadian Disruption is a Problem with Dr. Satchin Panda (01:59) Fasting & weight loss with Dr. Courtney Peterson (08:26) Optimal fasting window with Dr. Satchin Panda (15:49) Nutrition science claims with Dr Gil Carvalho (36:49) Diet & metabolic health with Dr. Richard Johnson (51:32) Cholesterol & CVD with Dr Alan Flanagan and Danny Lennon (57:22) Lowering cholesterol with Dr. David Jenkins (1:14:06) Gut microbiome with Drs. Erica and Justin Sonnenburg (1:24:44) Fibre & inflammation with Dr. Sonnenburg and Dr. Gardner (1:32:43) Fermented foods (1:49:35) Building microbiome diversity with Drs. Erica and Justin Sonnenburg (1:50:26) Simple dietary advice with Dr Tim Spector (1:55:57) Muscle & metabolic health with Dr. Donald Layman (1:58:34) Aging pathways with Dr. Valter Longo (2:07:24) Muscle & aging with Drs. Stuart Phillips and Christopher Gardner (2:14:48) Outro (2:20:11) Episodes featured: Episode #221 with Dr Satchin Panda Episode #232 with Dr Courtney Peterson Episode #207 with Dr Gil Carvhalo Episode #233 with Dr Richard Johhson Episode #231 with Dr Alan Flanagan & Danny Lennon Episode #216 with Dr David Jenkins Episode #202 with Dr Erica Sonnenburg & Dr Justin Sonnenburg Episode #191 with Dr Justin Sonnenburg & Dr Christopher Gardner Episode #224 with Dr Tim Spector Episode #236 with Dr Don Layman Episode #237 with Dr Valter Longo Episode #228 with Dr Stuart Phillips & Dr Christopher Gardner I hope you find this episode helpful for consolidating some of the key learnings from 2022.Part 2 of the year in review will be released next week with a focus on exercise, planetary health and more.Happy new year.Enjoy, friends.SimonWant to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary two-week meal plan and high protein Plant Performance recipe book

Episode #233. Dive deeper into how saturated fats and sugar affect metabolism and the liver in this conversation with Dr Richard Johnson. The Proof community had many questions after Dr Johnson’s appearance on Episode #215, and we return today to answer them: What does human outcome data say? What are the risks of the keto diet and high blood sugar? Do our opinions align?We answer these questions and more, addressing: Intro (0:00) Dr. Johnson’s Thesis on Fructose (3:27) Gaps in Current Studies (11:28) Saturated Fat Versus Sugar (20:20) Long-term risk of Keto Diet (33:09) Fructose Effect on Saturated Fat (36:28) Survival Mechanisms (40:40) Type of Fat (46:37) Metabolic Health & Fructose (53:00) Role of the Liver (1:02:20) Problem with High Blood Sugar (1:09:15) Triglycerides & Uric Acid (1:17:22) When Fatty Liver Happens (1:27:52) Ceramides (1:31:45) Outro (1:33:30) To connect with Dr Richard Johnson, you can find him on Instagram and Twitter, or learn more on his website. For a more comprehensive picture of Dr Johnson’s stance, make sure to check out his book, Nature Wants Us To Be Fat.Discover additional resources, supporting studies, and more insights in the full show notes.Enjoy, friends.SimonWant to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends.Simon Hill, Msc, Bsc (Hons)Creator of TheProof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube, or Listen on Apple/SpotifyConnect with me on Instagram, Twitter and FacebookDownload my complimentary two week meal plan and high protein plant performance recipe book