Dr. Dominic D'Agostino, a leading expert on ketogenic diets, dives deep into the science of keto and its myriad benefits. He clarifies the types of ketogenic diets and discusses the importance of biomarkers for optimizing health. The conversation explores how ketones enhance brain function, exercise performance, and even their potential therapeutic roles in neurodegenerative diseases and cancer. D'Agostino shares personal insights and practical tips for those looking to harness the power of a well-designed ketogenic diet.

Dr. Dominic “Dom" D’Agostino (@DominicDAgosti2) is an Assistant Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a Senior Research Scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast. He’s a beast and — no big surprise — he’s a good buddy of Dr. Peter Attia, my MD friend who drinks "jet fuel" in search of optimal athletic performance. The primary focus of Dom's laboratory is developing and testing metabolic therapies, including ketogenic diets, ketone esters and ketone supplements to induce nutritional/therapeutic ketosis. D’Agostino’s laboratory uses in vivo and in vitro techniques to understand the physiological, cellular and molecular mechanism of metabolic therapies and nutritional strategies for peak performance and resilience. His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations. Show notes and links for this episode can be found at www.fourhourworkweek.com/podcast. This podcast is brought to you by Audible. I have used Audible for years and I love audio books. I have 2 to recommend: The Graveyard Book by Niel Gaiman Vagabonding by Rolf Potts All you need to do to get your free audiobook and a free 30-day trial is go to Audible.com/tim. Choose one of the above books, or choose between more than 180,000 audio programs. That could be a book, a newspaper, a magazine or even a class. It's that easy. Go to Audible.com/Tim and get started today. Enjoy! This podcast is also brought to you by 99Designs, the world’s largest marketplace of graphic designers. I have used them for years to create some amazing designs. When your business needs a logo, website design, business card, or anything you can imagine, check out 99Designs. I used them to rapid prototype the cover for The 4-Hour Body, and I've also had them help with display advertising and illustrations. If you want a more personalized approach, I recommend their 1-on-1 service, which is non-spec. You get original designs from designers around the world. The best part? You provide your feedback, and then you end up with a product that you're happy with or your money back. Click this link and get a free $99 upgrade. Give it a test run… Enjoy!***If you enjoy the podcast, would you please consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it really makes a difference in helping to convince hard-to-get guests. I also love reading the reviews!For show notes and past guests, please visit tim.blog/podcast.Sign up for Tim’s email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Interested in sponsoring the podcast? Visit tim.blog/sponsor and fill out the form.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Insulin resistance is when cells stop responding to insulin’s signal to uptake glucose. It’s a hallmark of prediabetes, Type 2 diabetes, and other forms of metabolic dysfunction, and it manifests as several chronic disease, ranging from Alzheimer’s to polycystic ovarian syndrome. Dr. Rob Lustig and Dr. Dominic D’Agostino discuss the importance of monitoring insulin levels, why a high or increasing insulin level is a problem, and how insulin resistance hinders weight management. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 🎙 What Rob Lustig, MD, & Dr. Dominic D’Agostino, PhD, discuss: (03:57) — What is insulin? (06:55) — What is insulin resistance? (18:00) — There are three types of insulin resistance (38:00) — Weight management is not about calories in and calories out (45:53) — Adding more insulin to the equation of Type 2 diabetes isn’t necessarily the answer (51:20) — Insulin is a crucial biomarker to measure for metabolic health (53:58) — Insulin resistance is a hinderance to weight management (57:07) — The intake of too much leucine can lead to insulin resistance (1:02:04) — Fiber feeds the gut microbiome and is crucial for metabolic health (1:13:11) — Is intermittent fasting necessary? Transcripts & Show notes 🔗 Helpful links: Watch the conversation: https://youtu.be/dFOaBrujDHo Find us on YouTube: https://youtube.com/levelshealth?sub_confirmation=1 📲 Connect: Connect with Robert Lustig, MD, on Instagram: https://www.instagram.com/robertlustigmd/ Connect with Robert Lustig, MD, on Twitter: https://twitter.com/RobertLustigMD Connect with Dominic D’Agostino, PhD, on Instagram: https://www.instagram.com/dominic.dagostino.kt/ Connect with Dominic D’Agostino, PhD on Twitter: https://twitter.com/DominicDAgosti2

Dr. Rob Lustig and Dr. Dominic D’Agostino discuss insulin resistance, its impact on chronic diseases, the importance of monitoring insulin levels, and the role of insulin in weight management. They challenge traditional calorie theories, emphasize the need to manage insulin levels, and explore the effects of amino acids on metabolism.

Dr. Georgia Ede and Dr. Dominic D’Agostino discuss the connection between diet and brain health, the benefits of ketogenic diet for mental health, tailoring diets to prevent side effects, the link between gut health and mental health, and the importance of individualized nutrition in improving overall well-being.

Dr. Georgia Ede and Dr. Dominic D’Agostino discuss the connection between diet and brain health, specifically the benefits of a ketogenic diet. They delve into topics such as how the ketogenic diet can ease symptoms of mental health conditions, the connection between gut health and brain health, and the individualized nature of dietary needs. They also touch on the use of Continuous Glucose Monitoring (CGM) to track diet and health.

The ketogenic diet may help reduce depression and other symptoms in bipolar disorder. The ketogenic diet also helps metabolic health and reduces the risk for cardiometabolic diseases. The risk for cardiometabolic diseases is elevated in people with bipolar disorder when compared to the general population. Dr. Iain Campbell, Dr. Bret Scher, and Dr. Dominic D’Agostino discuss how the state of ketosis has beneficial effects on brain neurotransmitters and how those benefits have been life-changing physically and mentally for Dr. Campbell, who has bipolar disorder. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl 🎙 What Iain Campbell, MD, PhD, Bret Scher, MD & Dominic D’Agostino, PhD discuss: (05:40) — Dr. Iain Campbell explains how a ketogenic diet improved his mental health (09:02) — Dr. Campbell explains his pilot trial on the ketogenic diet and bipolar disorder (16:20) — The ketogenic diet is often misunderstood (18:10) — Elevated lactate is a biomarker in bipolar disorder (24: 37) — Circadian rhythm disruption affects bipolar disorder (30:33) — Morning exercise can help blunt the dawn glucose rise (38:48) — The ketogenic diet has effects on brain neurotransmitters (43:34) — Dr. Campbell explains ketosis helps him combat depression (46:42) — Dr. Campbell describes why he went on the ketogenic diet Transcripts & Show notes 👋 WHO WE ARE: Levels helps you see how food affects your health. With real-time, personalized data gathered through biosensors like continuous glucose monitors (CGM), you learn which diet and lifestyle choices improve your metabolic health so you can live a longer, fuller, healthier life. 🔗 LINKS: Watch the conversation: https://youtu.be/SAI6qeBMJFo Find us on YouTube: https://youtube.com/levelshealth?sub_confirmation=1 📲 Connect: Connect with Iain Campbell, MD, PhD, on Twitter: https://twitter.com/IainCampbellPhD Connect with Bret Scher, MD, on Twitter: https://twitter.com/bschermd/ Connect with Bret Scher, MD, on Instagram: https://www.instagram.com/drbretscher/ Connect with Dominic D’Agostino, PhD, on Twitter: https://twitter.com/DominicDAgosti2 Connect with Dominic D’Agostino, PhD on Instagram: https://www.instagram.com/dominic.dagostino.kt/

Dr. Dominic D’Agostino, a research scientist, discusses topics such as NASA's underwater missions, prioritization challenges for entrepreneurs, the benefits of ketones as an alternative fuel source, the anti-inflammatory mechanisms of ketones, mean amplitude glucose excursions, and the advantages of a ketogenic diet for mitochondrial health and well-being.

Dave Feldman, Dr. Nick Norwitz & Dr. Dominic D’Agostino discuss the lean mass hyper-responder phenotype, Oreo vs statin study, role of exercise, alarming LDL levels, gym hypothesis, and the need for further research on ketogenic diets and cholesterol impact on health.

Dr. Dominic D’Agostino is a leading expert in ketogenic science and metabolic therapy. He discusses how ketones serve as effective fuel and signaling molecules, promoting fat loss and muscle preservation. Dr. D’Agostino emphasizes his daily pursuit of ketosis and explores the dynamics between protein and ketones. Listeners dive into appetite suppression on a keto diet, the benefits of exogenous ketones, and the role of strength training. He also shares insights on the latest science behind ketosis for performance, metabolic health, and aging.