Paul Saladino MD podcast
3. Supersoldiers and enhanced cognitive function with ketones! A conversation with Dominic D’Agostino, PhD
Jul 23, 2019
Dr. Dominic D’Agostino, a research scientist, discusses topics such as NASA's underwater missions, prioritization challenges for entrepreneurs, the benefits of ketones as an alternative fuel source, the anti-inflammatory mechanisms of ketones, mean amplitude glucose excursions, and the advantages of a ketogenic diet for mitochondrial health and well-being.
01:39:22
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Quick takeaways
- Transitioning to a low carbohydrate diet leads to the production of ketones, which can be used as fuel by the brain, heart, and muscles, promoting metabolic flexibility.
- Ketones have anti-inflammatory and epigenetic effects, activating antioxidant systems, regulating gene expression, and suppressing pro-inflammatory pathways.
Deep dives
Metabolic flexibility and adaptation to ketosis
When someone transitions to a low or zero carbohydrate diet, there is an initial drop in blood glucose levels. The body then begins to suppress insulin and elevate glucagon, mobilizing fatty acids for fuel. The liver produces ketone bodies through beta oxidation of fatty acids, which are released into the bloodstream. Ketones can be used as fuel by the brain, heart, and muscles. With prolonged ketosis, the body adapts to using ketones as its primary fuel source, leading to metabolic flexibility.
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