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LEVELS – A Whole New Level

#253 - What is insulin resistance and why does it matter? | Dr. Rob Lustig & Dr. Dominic D’Agostino - (Replay)

May 9, 2024
Dr. Rob Lustig and Dr. Dominic D’Agostino discuss insulin resistance, its impact on chronic diseases, the importance of monitoring insulin levels, and the role of insulin in weight management. They challenge traditional calorie theories, emphasize the need to manage insulin levels, and explore the effects of amino acids on metabolism.
01:17:17

Podcast summary created with Snipd AI

Quick takeaways

  • Insulin resistance is a crucial marker for metabolic health, hindering weight management and linked to various chronic diseases.
  • Recognizing the diverse tissue-specific manifestations of insulin resistance is essential in addressing related health issues effectively.

Deep dives

Insulin Resistance and Liver Fat

Insulin resistance is intricately linked to liver fat accumulation, leading to a cascade of health issues. The primary target of insulin action is the liver, where excess fat accumulation impairs liver function, necessitating higher insulin production. The resulting insulin resistance manifests in various diseases like type 2 diabetes, PCOS, cardiovascular diseases, and even Alzheimer's. Understanding and addressing liver fat becomes crucial in combating insulin resistance.

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