Insulin resistance is when cells stop responding to insulin’s signal to uptake glucose. It’s a hallmark of prediabetes, Type 2 diabetes, and other forms of metabolic dysfunction, and it manifests as several chronic disease, ranging from Alzheimer’s to polycystic ovarian syndrome. Dr. Rob Lustig and Dr. Dominic D’Agostino discuss the importance of monitoring insulin levels, why a high or increasing insulin level is a problem, and how insulin resistance hinders weight management. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 🎙 What Rob Lustig, MD, & Dr. Dominic D’Agostino, PhD, discuss: (03:57) — What is insulin? (06:55) — What is insulin resistance? (18:00) — There are three types of insulin resistance (38:00) — Weight management is not about calories in and calories out (45:53) — Adding more insulin to the equation of Type 2 diabetes isn’t necessarily the answer (51:20) — Insulin is a crucial biomarker to measure for metabolic health (53:58) — Insulin resistance is a hinderance to weight management (57:07) — The intake of too much leucine can lead to insulin resistance (1:02:04) — Fiber feeds the gut microbiome and is crucial for metabolic health (1:13:11) — Is intermittent fasting necessary? Transcripts & Show notes 🔗 Helpful links: Watch the conversation: https://youtu.be/dFOaBrujDHo Find us on YouTube: https://youtube.com/levelshealth?sub_confirmation=1 📲 Connect: Connect with Robert Lustig, MD, on Instagram: https://www.instagram.com/robertlustigmd/ Connect with Robert Lustig, MD, on Twitter: https://twitter.com/RobertLustigMD Connect with Dominic D’Agostino, PhD, on Instagram: https://www.instagram.com/dominic.dagostino.kt/ Connect with Dominic D’Agostino, PhD on Twitter: https://twitter.com/DominicDAgosti2

Dr. Rob Lustig and Dr. Dominic D’Agostino discuss insulin resistance, its impact on chronic diseases, the importance of monitoring insulin levels, and the role of insulin in weight management. They challenge traditional calorie theories, emphasize the need to manage insulin levels, and explore the effects of amino acids on metabolism.

Fructose and its byproduct uric acid may play a role in the development of Alzheimer’s, thanks to an evolutionary adaptation hijacked by the modern diet. Fructose can be directly consumed, or the body can convert high-glycemic carbohydrates and other foods to fructose. Fructose suppresses some cognitive functions. Dr. Richard Johnson and Dr. Rob Lustig discuss a new study, of which Johnson was an author, on how fructose may be a potential driver in Alzheimer’s, and they hypothesize about fructose’s potential connection to the development of other conditions. Sign Up to Get Your Free Ultimate Guide to Glucose: https://levels.link/wnl 🎙 What Richard Johnson, MD, & Rob Lustig, MD, discuss: (09:50) — Fructose is the driver of some diseases that are on the rise in kids (11:53) — Fructose is a driver of obesity and metabolic syndrome (15:36) — Pharmaceutical treatments for Alzheimer’s disease aren’t as effective as researchers had hoped (17:32)— The research focus of Alzheimer’s is slowly shifting to understanding insulin resistance in the brain (20:41) — Is fructose a root cause of Alzheimer’s? (26:26) — New research suggests fructose induces a foraging response (28:20) — Fructose inhibits areas of the brain to encourage successful foraging (46:48) — We need more research on fructose (1:03:10) —Is fructose a factor in violence? Transcripts & Show notes Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 👋 WHO WE ARE: Levels helps you see how food affects your health. With real-time, personalized data gathered through biosensors like continuous glucose monitors (CGM), you learn which diet and lifestyle choices improve your metabolic health so you can live a longer, fuller, healthier life. 🔗 LINKS: Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?: https://www.sciencedirect.com/science/article/abs/pii/S0002916523000047?dgcid=author Subscribe here on YouTube: https://youtube.com/levelshealth?sub_confirmation=1 📲 CONNECT: Connect with Richard Johnson, MD, on Instagram: https://www.instagram.com/drrichardjjohnson/ Connect with Robert Lustig, MD, on Instagram: https://www.instagram.com/robertlustigmd/

Dr. Richard Johnson and Dr. Rob Lustig discuss how fructose could be a driver of Alzheimer's disease. They explore fructose's impact on obesity, metabolic syndrome, and cognitive functions, suggesting a potential connection to other conditions. The podcast delves into new research on fructose inducing a foraging response in the brain and its inhibitory effects, raising the question of fructose's role in various health issues beyond Alzheimer's.

Dr. Rob Lustig and Dr. Casey Means discuss how environmental chemicals directly cause obesity, the impact of these toxins on metabolic dysfunction, and the importance of protecting ourselves. They highlight the presence of obesogens in everyday products and the potential effects on our offspring. They also emphasize the need for screening and regulating industrial chemicals and raise awareness about the presence of chemicals in our daily lives.