The Neuro Experience

The Fasting Expert: Why Women Should NEVER Fast at this time | Dr. Mindy Pelz

Jan 20, 2026
Dr. Mindy Pelz, a bestselling author and hormone expert specializing in fasting and women's health, dives into the controversial topic of fasting for women. She reveals how fasting can adversely affect hormonal cycles, leading to issues like hair loss and missed periods. Mindy discusses the unique needs of women's brains during menopause, emphasizing the critical role of ketones. She also outlines practical fasting durations and introduces a tailored fasting cycle for women, highlighting why understanding hormonal changes is key to metabolic health.
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INSIGHT

Two Distinct Metabolic Modes

  • The body has two metabolic systems: a glucose 'sugar burner' and a ketogenic 'fat burner' that activates after ~12 hours without glucose spikes.
  • Fasting timings act as metabolic signals that shift fuel use and hormonal production across the body and brain.
INSIGHT

Brain Shifts To Ketones In Menopause

  • During menopause the brain's glucose metabolism can fall and the brain may catabolize myelin to make ketones for fuel.
  • Introducing ketones (endogenous or exogenous) can rapidly restore brain function when glucose utilization declines.
ADVICE

Use Longer Fasts For Cellular Repair

  • Autophagy and mitophagy peak between about 17 and 72 hours without food, producing cellular repair and mitochondrial cleanup.
  • Use longer fast windows selectively for deeper repair, e.g., 48–72 hours for cognitive recovery under supervision.
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