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The Peter Attia Drive

#283 ‒ Gut health & the microbiome: improving and maintaining the microbiome, probiotics, prebiotics, innovative treatments, and more | Colleen Cutcliffe, Ph.D.

Dec 18, 2023
0
02:32:41
Snipd AI
Colleen Cutcliffe, expert in molecular biology and co-founder of Pendulum Therapeutics, discusses the complexity of the microbiome, the role of probiotics and prebiotics, the importance of a high-fiber diet, the potential of fecal microbiota transplant (FMT), and the challenges in manufacturing and maintaining bacteria strains. She also explores the role of acromancia in the gut microbiome, the efficacy of probiotics in improving GI symptoms, and the impact of high fiber and high polyphenol foods on gut health.
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Podcast summary created with Snipd AI

Quick takeaways

  • Fecal microbiome transplants (FMT) are a highly successful treatment for Clostridium difficile infections, but concerns about safety and regulation need to be addressed.
  • The gut microbiome relies on the metabolism of insoluble fibers, such as butyrate, for gut health, which can be supplemented through diet or capsules.

Deep dives

Fecal Microbiome Transplants and C. Difficile

Fecal microbiome transplants (FMT) have proven to be a highly successful treatment for Clostridium difficile infections. C. difficile is a strain of bacteria that can thrive when other bacteria in the gut are wiped out by antibiotics. FMT involves transplanting feces from a healthy donor into the gut of an infected individual, restoring a healthy balance of bacteria and resolving the infection. While FMT has a success rate of nearly 99%, concerns have been raised about the safety and regulation of the procedure. The source of the donor feces and potential transfer of pathogens or unintended changes to the recipient's metabolism are points of caution that need to be addressed.

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