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Rhythm Control Gains From Ablation
- Early trials showed no difference between rate and rhythm control but had major caveats like limited ablation use.
- Recent ablation trials show reduced AF burden and mortality benefit when sinus rhythm is maintained.
Ablation Focus And Burden Threshold
- Pulmonary vein isolation has been the cornerstone of AF ablation since the late 1990s and techniques evolved around the posterior wall.
- Ablation need not eliminate AF completely; reducing burden below ~50% yields clinical benefit.
Match Early-Diagnosis Criteria
- The Korean study limited participants to new users of rate or rhythm therapies diagnosed within one year to match EAST-AFNET 4 criteria.
- Use early diagnosis (within one year) as a key inclusion when comparing rhythm versus rate strategies.