Dr. Centor discusses the evidence that implementation of the SEP-1 Bundle is associated with favorable outcomes for patients with sepsis with Drs. James Ford and Gabriel Wardi.

Dr. Centor discusses metabolic dysfunction-associated steatotic liver disease with Dr. Michelle Lai.

Dr. Centor discusses factors associated with physician burnout with Dr. Christine Sinsky.

Dr. Centor discusses teaching diagnostic reasoning with Drs. Rabih Geha and Reza Manesh.

Dr. Centor discusses evidence-based treatment of low back pain with Dr. Roger Chou.

Dr. Centor discusses diagnostic reasoning with Dr. Jerome Kassirer.

Dive into the intriguing world of diagnostic reasoning as experts explore its critical evolution. A memorable internship case highlights how pivotal diagnostic skills can change outcomes. The journey from laboratory research to real-world clinical decision-making underscores the importance of collaboration. As the conversation unfolds, listeners gain insight into the complexities of diagnostic trade-offs and how these influence treatment choices. Overall, the discussion emphasizes the necessity for accurate diagnoses to enhance patient care.

Dr. Jeffrey Carson, a distinguished transfusion researcher, and Dr. Maria Maury-Brooks, an expert in epidemiological data, dive deep into transfusion thresholds in myocardial infarction. They discuss critical strategies to optimize patient care and the implications of recent studies on hemoglobin levels. The conversation covers a comparison of liberal versus restrictive transfusion strategies and innovative statistical methods aimed at reducing biases in clinical trials. Ultimately, they advocate for tailored approaches to transfusion that consider individual patient conditions.

Dr. Centor discusses why guidelines recommending that clinicians advise patients on lifestyle changes may be a questionable approach to improving public health with Dr. Minna Johansson.

Mark Sarnak, Chief of Nephrology at Tufts School of Medicine, dives deep into the role of renin-angiotensin system blockade in advanced chronic kidney disease. He discusses the complexities and risks associated with using ACE inhibitors and ARBs, particularly hyperkalemia and acute kidney injury. Highlighting meta-analyses, he reveals significant reductions in kidney failure events with these treatments. The conversation also covers new insights into potassium management and the promising role of SGLT2 inhibitors, capturing the optimism in nephrology communities.