Dr. Centor discusses diagnostic reasoning with Dr. Jerome Kassirer.

Dive into the intriguing world of diagnostic reasoning as experts explore its critical evolution. A memorable internship case highlights how pivotal diagnostic skills can change outcomes. The journey from laboratory research to real-world clinical decision-making underscores the importance of collaboration. As the conversation unfolds, listeners gain insight into the complexities of diagnostic trade-offs and how these influence treatment choices. Overall, the discussion emphasizes the necessity for accurate diagnoses to enhance patient care.

Dr. Jeffrey Carson, a distinguished transfusion researcher, and Dr. Maria Maury-Brooks, an expert in epidemiological data, dive deep into transfusion thresholds in myocardial infarction. They discuss critical strategies to optimize patient care and the implications of recent studies on hemoglobin levels. The conversation covers a comparison of liberal versus restrictive transfusion strategies and innovative statistical methods aimed at reducing biases in clinical trials. Ultimately, they advocate for tailored approaches to transfusion that consider individual patient conditions.

Dr. Centor discusses why guidelines recommending that clinicians advise patients on lifestyle changes may be a questionable approach to improving public health with Dr. Minna Johansson.

Dr. Centor discusses reninbngiotensin system blockade in persons with advanced chronic kidney disease with Drs. Elaine Ku and Mark Sarnak.

Eileen Barrett, an expert in internal medicine and former chair of the American College of Physicians Board of Regents, joins Amanda Collar, an internal medicine intern and kratom researcher. They unpack the recreational uses of kratom, noting its methods of consumption and its potential for pain relief. The discussion dives into the regulatory challenges and health risks associated with kratom, as well as its complex role as a possible gateway substance. Emphasis is placed on improving physician-patient communication and the urgent need for further research on kratom's safety.

Dr. Centor discusses the importance of physician humility with Dr. Caroline Matchett.

Dr. Barbara Jones, an associate professor at the University of Utah specializing in pulmonary and critical care, dives into the intricate world of diagnosing community-acquired pneumonia. She highlights the clinical challenges that arise from overlapping symptoms, especially in older patients. The conversation reveals how misdiagnoses can occur in emergency settings and introduces innovative tools like natural language processing to enhance diagnostic accuracy. The importance of communication and patient involvement in navigating diagnostic uncertainty is emphasized throughout.

Dr. Centor discusses the diagnosis of giant cell arteritis with Dr. Sebastian Sattui.

Nadia Daneshvar, an expert in the responsible use of AI in healthcare, joins Deepti Pandita, a medical professional, to discuss critical topics surrounding AI integration in medicine. They highlight the ethical and legal frameworks necessary for effective AI application. The conversation emphasizes the need for human oversight in clinical decision-making and the importance of personalized healthcare. They also explore the transition to value-based care and the challenges posed by opaque AI processes, advocating for improved education and the crucial role of physicians.