The Jesse Chappus Show 666: Hormone Expert: The Fastest Way to Insulin Resistance & the Big Lie About Calories! | Dr. Robert Lustig
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Aug 19, 2025 
Dr. Robert Lustig, a neuroendocrinologist and bestselling author, dives deep into the myths surrounding insulin resistance and calorie counting. He uncovers how dysfunctional mitochondria contribute to metabolic issues and critiques the impact of ultra-processed foods on fat storage. Lustig reveals the interplay between hormones like cortisol and insulin in fat accumulation, discusses the harmful effects of fructose from sugary drinks, and emphasizes the critical role of fiber in improving metabolic health. Intermittent fasting also gets a nod for its potential benefits on liver health.
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Insulin Drives Energy Storage Not Burning
- Insulin is an energy-storage hormone that diverts fuel away from mitochondria and drives fat and glycogen storage.
- Chronic high insulin signals mitochondrial dysfunction and links to metabolic syndrome diseases.
Different Fat Depots, Different Dangers
- Subcutaneous, visceral, and liver fat differ in cause and metabolic risk.
- About 22 lb subcutaneous, 4 lb visceral, and ~0.5 lb liver fat produce comparable metabolic harm.
Three Kinases Decide Growth Or Burning
- PI3K, AMPK, and mTOR coordinate growth vs. burning; dyssynchrony of these kinases causes chronic disease.
- Mitochondrial ROS and metabolic status set their phosphorylation and thus cell fate.