The Dr. Gundry Podcast

Are Butyrate Supplements Effective? - Dr. Gundry's Quick Health Tip | EP 367.B

Sep 4, 2025
Discover the fascinating role of butyrate in colon health and its potential in cancer prevention. Explore the alarming rise of colon cancer among younger populations and the impact of modern diets on gut flora. Learn about the crucial link between fiber types, butyrate production, and overall colon wellness. Uncover insights on targeted delivery of supplements versus dietary sources, and how maintaining healthy gut bacteria can significantly enhance health. Plus, appreciate the surprising connections between bone health and immune function.
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INSIGHT

Butyrate Is Essential For Colon Cells

  • Butyrate is a short-chain fatty acid that colonocytes use for ~90% of their energy needs.
  • Butyrate also acts as a powerful inhibitor of colon cancer cell growth by functioning as an HDAC inhibitor.
INSIGHT

Microbial Loss Raises Colon Cancer Risk

  • Loss of butyrate-producing bacteria leaves colonocytes starved and vulnerable to damage.
  • Reduced butyrate also removes a key brake on precancerous cells, contributing to rising colon cancer rates.
ANECDOTE

Field Observation In Africa

  • Dennis Burkett found almost no colon disease in Africans who ate lots of yams and tubers.
  • He linked their high soluble-fiber diets to dramatically lower colon disease rates compared to England.
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