EB. 114: Fat-Burning Drives Insulin Resistance And Eating Carbohydrates Improves Insulin Sensitivity

Apr 30, 2024

Topics discussed include the benefits of increasing carbohydrate intake on insulin sensitivity, the role of stress hormones in driving insulin resistance, and the impact of fatty acid oxidation on liver and cardiovascular health. Contrary to popular belief, strategies like intermittent fasting and cold plunges may not effectively improve insulin sensitivity.

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Introduction

00:00 • 5min

Understanding the Role of Glucagon in Metabolic Dysfunction

05:29 • 17min

Exploring the Interplay of Cortisol, Glucocorticoids, and Insulin Sensitivity along with the Controversy of Carbohydrate Intake

22:49 • 3min

Exploring Glucose Tolerance and Insulin Sensitivity with High Sucrose Diets

26:12 • 4min

Enhancing Insulin Sensitivity Through High Carbohydrate Feeding

29:52 • 5min

Understanding Fat-Burning, Insulin Resistance, and Carbohydrate Consumption in Liver Pathologies

34:26 • 18min

Discussing Cellular Dysfunction and Disease State Pathology

52:06 • 5min

In this episode we discuss:

How increasing carbohydrate intake actually improves insulin sensitivity, even in people with type 2 diabetes
The research showing that fatty liver disease and cardiovascular disease are both characterized by excess fatty acid oxidation
The research showing that fatty liver disease and cardiovascular disease are both characterized by excess fatty acid oxidation
Why strategies such as intermittent fasting, cold plunges, and OMAD (one meal a day) are not effective for improving insulin sensitivity

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-114-fat-burning-drives-insulin-resistance-and-eating-carbohydrates-improves-insulin-sensitivity/

Timestamps:

0:00 – intro

1:17 – stress hormones (glucagon, epinephrine, and cortisol) are major contributors to insulin resistance and diabetes

4:05 – elevated glucagon levels, not carbohydrates, are the driving force behind high fasting blood glucose levels

6:43 – glucagon is a driver of insulin resistance, while insulin is just a symptom

12:46 – the research showing that blocking stress hormones directly improves insulin sensitivity

15:14 – “hormetic” stressors like intermittent fasting, cause insulin resistance

19:30 – fat burning drives insulin resistance and keeps us in a catabolic state, driving weight gain and muscle wasting

22:15 – cortisol drives insulin resistance and why serum cortisol levels don’t provide the full picture

25:00 – low-carb diets reduce insulin sensitivity while carbohydrate intake improves it

29:40 – decreasing fatty acid oxidation by increasing carb intake improves our ability to tolerate carbohydrates

33:46 – burning fat contributes to increased disease processes and does not lead to losing more body fat

38:04 – fatty acid oxidation damages our mitochondria and increases fat storage

46:22 – type 2 diabetes directly contributes to heart disease by upregulating fatty acid oxidation

52:05 – how to decrease fatty acid oxidation and improve glucose metabolism