The Ready State Podcast Gut Health, Energy & Brain Fog: Dr. Amy Shah on Microbiome, Ultra-Processed Foods, and Circadian Fasting
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Sep 18, 2025 
Dr. Amy Shah, a double board-certified physician and bestselling author, unveils how the gut microbiome influences energy and wellness. She discusses the detrimental effects of ultra-processed foods on mood and immunity. Learn about the 'energy trifecta'—the critical connection between gut health, immune function, and hormones. Dr. Shah emphasizes practical tips like her 30/30/3 rule to boost nutrition. She also highlights the importance of aligning eating with circadian rhythms for optimal health, including the role of early microbial exposures in preventing allergies.
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Why Ultra-Processed Foods Hurt Us
- Ultra-processed foods contain ingredients that cannot be made in a home kitchen and disrupt gut and mood.
- High intake links to sadness, anxiety, cardiometabolic disease, and early mortality.
Early Microbial Exposure Trains Immunity
- Early-life exposure to dirt, animals, and microbes trains the immune system and builds a resilient microbiome.
- Children raised on farms showed stronger immunity and fewer allergies in studies.
Pacifier Study Validated A River-Guide Tip
- Juliet recalled a river guide who said pick food off the ground and eat it to build immune strength.
- Dr. Shah cited a pacifier-licking study showing early microbial exposure strengthened babies' immunity.
