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Sigma Nutrition Radio
#495: Circadian Clocks in Muscle & Exercise as a Time Cue – Prof. Karyn Esser
Sep 12, 2023
35:27
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Quick takeaways
- Exercise can shift the phase of muscle clocks and regulate gene expression, highlighting the intrinsic capacity of muscle cells to respond to exercise-related cues and suggesting the role of clock mechanisms in exercise adaptations.
- Circadian phase differences in muscle strength and mitochondrial function indicate the potential trainability and adaptability of muscle clocks through exercise, emphasizing the importance of considering circadian factors in training schedules for optimal performance.
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Exercise and Circadian Rhythms in Muscle
Exercise has a significant impact on circadian rhythms in skeletal muscle. Studies have shown that exercise can shift the phase of the muscle clocks and regulate gene expression. An experiment with mice exercising during their normal sleep phase demonstrated a significant shift in the muscle clocks, closer to the time of exercise. Another study using acute bouts of exercise at different times of day showed that exercise can induce phase advances or delays in the muscle clocks. Furthermore, muscle cells grown in vitro also exhibited the ability to sense contractions and adjust their clock phase accordingly. This highlights the intrinsic capacity of muscle cells to respond to exercise-related cues and suggests that the clock mechanisms play a role in exercise adaptations in muscle.
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