AI Snips
Chapters
Transcript
Episode notes
Early Blood Ingestion Experiments
- In 1939, Leon Schiff conducted experiments where participants ingested three-week-old blood.
- He observed a dose-dependent rise in BUN based on the amount of blood ingested.
Self-Blood Ingestion Experiment
- Captain I.J. Greenblatt conducted studies in 1946 where military officers drank their own blood after phlebotomy.
- The BUN increased with larger blood volumes (800 mL) but not significantly with smaller volumes (580 mL).
Site of Blood Administration and BUN
- Leon Schiff's experiments showed that administering blood into the stomach or upper small bowel increased BUN.
- However, colonic administration showed no BUN elevation, suggesting the importance of the upper GI tract.