Dr. William Hsu, an experienced endocrinologist and Chief Medical Officer at L-Nutra, shares insights on nourished fasting. He explains how this fasting mimicking diet can reduce insulin resistance and activate autophagy, promoting cellular repair while still providing nourishment. The discussion touches on the influence of nutrient-sensing pathways on metabolic health and the impact of modern eating habits on aging. Dr. Hsu highlights practical applications of nourished fasting for improving healthspan and emphasizes the importance of lifestyle medicine.
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volunteer_activism ADVICE
Avoid Seed Oils for Cooking
Avoid cooking with seed oils like canola or corn as they are toxic and inflammatory.
Use stable, nutrient-dense fats like 100% grass-fed beef tallow for cooking at high heat.
insights INSIGHT
Body's Self-Healing via Fasting
The body has innate ability to heal if the right environment is created.
Fasting is a lifestyle medicine intervention enabling the body to heal itself naturally.
insights INSIGHT
Nutrient Sensing Accelerates Aging
Cells activate growth pathways when sensing nutrients like glucose and amino acids.
Constant growth activation without breaks accelerates aging and wear on the body.
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In this episode, Dr. Jockers and Dr. William Hsu dive into how nourished fasting can reduce insulin resistance, activate autophagy, and slow aging. They discuss how the fasting mimicking diet triggers cellular repair while still providing nourishment.
Learn how nutrient-sensing pathways like mTOR and IGF-1 influence metabolic health and why modern eating habits may accelerate aging. Dr. Hsu explains how short-term fasting can promote healing by tapping into the body’s natural survival mechanisms.
Discover how to apply nourished fasting in your life with the ProLon protocol and why a few cycles a year can significantly improve your healthspan.
In This Episode:
00:00 Introduction to the Fast Mimicking Diet
02:49 Interview with Dr. William Hsu: Metabolic Health and Fasting
04:48 The Science Behind Fasting and Cellular Healing
06:49 The Evolutionary Perspective on Fasting
09:22 Understanding Nutrient Sensing Pathways
14:33 The Nobel Prize-Winning Research on Autophagy
17:44 The Concept of Fasting Mimicking Diet
21:25 Exploring the Benefits of Fasting Mimicking Diet
22:01 The Science Behind Fasting and Systemic Health
23:22 The Role of Lifestyle Medicine
24:16 Understanding Digestive Health and Stomach Acid
26:10 Hormetic Stress and Health Benefits
27:16 Clinical Research on Fasting Mimicking Diet
31:32 Practical Application of Fasting Mimicking Diet
32:43 Personalized Programs for Health Conditions
35:22 The Future of Lifestyle Medicine
40:54 Final Thoughts and Call to Action
Still cooking with seed oils? That could be fueling inflammation. I’ve switched to Paleovalley’s 100% grass-fed beef tallow—it’s rich in CLA, packed with flavor, and stable at high heat. It’s one of the cleanest, most nutrient-dense fats you can cook with. Head to paleovalley.com/jockers and use code JOCKERS for 15% off your order.
Heartburn doesn’t mean you have too much stomach acid—it usually means you don’t have enough. That’s why I recommend Just Thrive’s Digestive Bitters. They help ignite stomach acid, enzymes, and bile so you can finally break down food the way you’re supposed to. Go to justthrivehealth.com and use code JOCKERS to save 20%.
"Autophagy is your body’s self-cleaning cycle—and most people never turn it on."
Dr. Jockers Functional Nutrition