Core IM | Internal Medicine Podcast

#105 Sickle Cell: 5 Pearls Segment

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Jun 1, 2022
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INSIGHT

Malaria Hypothesis

  • Sickle cell trait persists because it protects against malaria.
  • The mutation makes red blood cells inhospitable to malarial parasites.
INSIGHT

Sickling Outcomes

  • Sickling has two main negative consequences: vaso-occlusion and hemolysis.
  • Vaso-occlusion occurs when sickled cells block microvasculature, while hemolysis results from inflexible RBC membranes.
ADVICE

Avoid Number-Based Transfusions

  • Avoid transfusing sickle cell patients solely based on a hemoglobin number.
  • Frequent transfusions lead to iron overload, organ damage, and alloimmunization.
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