Dr. Mark Mattson, a neuroscience professor at Johns Hopkins, shares his expertise on the benefits of intermittent fasting and metabolic switching. He highlights how mild stressors can enhance brain health and discusses the hormonal impacts of fasting, especially for women. The conversation extends to the significance of refeeding after fasting and the unique advantages of plant bioactive compounds. Mattson also emphasizes the synergy of exercise and fasting for optimal performance, addressing how these practices can adapt to different age groups and metabolic conditions.
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insights INSIGHT
Intermittent Fasting: A Pattern, Not a Diet
Intermittent fasting is an eating pattern, not a diet.
It involves cycling between metabolic challenge (fasting) and recovery (eating).
insights INSIGHT
Health Benefits of Fruits and Vegetables
Fruits and vegetables benefit health by inducing mild stress responses in cells.
These responses activate similar pathways as exercise and fasting, enhancing cellular defenses.
volunteer_activism ADVICE
Elderly and Intermittent Fasting
Prioritize exercise and a healthy diet, especially when aging.
Be cautious with intermittent fasting in the elderly and consider resistance training.
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Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientists in the world, with more than 180,000 citations noted in the scientific literature.
Dr. Mattson's work has advanced scientific understanding of brain aging and identified fundamental aspects of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting.
In this episode, we discuss...
(00:00) Introduction to Dr. Mark Mattson
(03:31) Hormetic stressors drive adaptation and prevent physiological complacency
(13:00) Intermittent fasting improves health by promoting metabolic switching
(16:49) Daily time-restricted eating vs 5:2 weekly fasting
(27:44) A ketogenic diet and intermittent fasting differ in terms of brain effects
(34:23) Exercising while intermittent fasting exerts additive effects
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