Dr. Mark Mattson Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientists in the world, with more than 180,000 citations noted in the scientific literature. Dr. Mattson's work has advanced scientific understanding of brain aging and identified fundamental aspects of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting. In this episode, we discuss... (00:00) Introduction to Dr. Mark Mattson (03:31) Hormetic stressors drive adaptation and prevent physiological complacency (13:00) Intermittent fasting improves health by promoting metabolic switching (16:49) Daily time-restricted eating vs 5:2 weekly fasting  (27:44) A ketogenic diet and intermittent fasting differ in terms of brain effects (34:23) Exercising while intermittent fasting exerts additive effects (52:32) Plant-based bioactive compounds induce hormetic stress (01:10:48) Severe caloric restriction may compromise muscle mass (01:26:25) Intermittent fasting in young vs. old and in men vs. in women (01:35:20) The effects of cortisol differ during a fast versus chronic stress (01:53:36) Fasting-mimetics like resveratrol and spermidine vs actual fasting (02:08:44) How ketone supplementation may improve brain health Join over 300,000 people and get the latest distilled information on circadian insights straight to your inbox weekly: https://www.foundmyfitness.com/newsletter Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor

Neuroscientist Mark Mattson discusses the pivotal role of glutamate in the brain, influencing cognitive functions and neurological disorders. He explains how glutamate controls learning, memory, creativity, and its involvement in disorders like autism and Alzheimer's. The discussion sheds light on the importance of understanding this neurotransmitter for brain health and function.

Neuroscientist Mark Mattson discusses the crucial role of Glutamate in brain growth, neuroplasticity, and Alzheimer's. They explore the importance of studying glutamate for understanding brain formation, learning, and memory. The conversation delves into the significance of glutamate in neuronal development, brain function, energy efficiency, and its potential for life on Titan. Mattson also touches on the role of glutamate in neurological disorders like epilepsy and Alzheimer's, highlighting the complexities of brain processing and consciousness.