

#07 - Deep Dive: Lp(a) — what every doctor, and the 10-20% of the population at risk, needs to know
27 snips Jul 30, 2018
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Lipoprotein Basics
- Lipoproteins like LDL and HDL are macrostructures that carry cholesterol in the bloodstream.
- Cholesterol is essential for cell membranes and hormone production, but it needs lipoproteins to be transported in the blood.
Lp(a) Structure
- Lp(a) is an LDL particle with a unique apolipoprotein(a) attached.
- This apo(a) varies in size due to repeating segments called 'cringle domains,' affecting Lp(a)'s mass and particle number.
Lp(a) Testing
- Test Lp(a) particle number, not just mass, for accurate risk assessment.
- High Lp(a) particle number, above 125 nmol/L, indicates increased risk.