The Peter Attia Drive

#07 - Deep Dive: Lp(a) — what every doctor, and the 10-20% of the population at risk, needs to know

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Jul 30, 2018
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INSIGHT

Lipoprotein Basics

  • Lipoproteins like LDL and HDL are macrostructures that carry cholesterol in the bloodstream.
  • Cholesterol is essential for cell membranes and hormone production, but it needs lipoproteins to be transported in the blood.
INSIGHT

Lp(a) Structure

  • Lp(a) is an LDL particle with a unique apolipoprotein(a) attached.
  • This apo(a) varies in size due to repeating segments called 'cringle domains,' affecting Lp(a)'s mass and particle number.
ADVICE

Lp(a) Testing

  • Test Lp(a) particle number, not just mass, for accurate risk assessment.
  • High Lp(a) particle number, above 125 nmol/L, indicates increased risk.
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