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Different Types And Stages Matter
- Cognitive decline includes normal age-related changes and disease-driven degeneration like dementia. Different stages and pathologies require different study designs and outcomes.
Prevention Focus Because Drugs Failed
- Drug trials for Alzheimer's have largely failed, shifting focus to prevention and mid-life interventions. Nutrition research now emphasizes supporting cognitive resilience earlier, before pathology appears.
APOE Links Genes, Cholesterol And Risk
- APOE genotype strongly modifies dementia risk, with APOE4 increasing and APOE2 decreasing risk. Cholesterol metabolism links APOE variants to amyloid processing and dietary fat effects.