Ep. 122: Weight Loss with Berberine & Urolithin A, Blood Sugar Spikes, & Pairing Protein with Carbs (Q&A)
Sep 5, 2024
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In this enlightening discussion, Berberine, known for its potential in weight loss and blood sugar control, and Urolithin A, noted for gut health benefits, share their insights. They explore the mechanisms by which Berberine lowers blood sugar and its role in gut health. The conversation also tackles the importance of pairing protein with carbohydrates and whether avoiding blood sugar spikes is necessary. Listeners learn about the benefits and complexities of these compounds, emphasizing a holistic approach to weight management.
Berberine and urolithin A show potential in weight loss efforts, but their long-term effects on health require cautious evaluation.
Berberine lowers blood sugar by impairing mitochondrial function, raising concerns about its overall impact on energy metabolism.
Pairing protein with carbs can stabilize blood sugar levels, though slight fluctuations may be normal for those without insulin resistance.
Deep dives
Berberine and Urolithin A for Weight Loss
Berberine and urolithin A are both polyphenolic compounds that have gained attention for their potential health benefits, including weight loss. Berberine is primarily found in herbs like goldenseal and is known to lower gluconeogenesis, which may benefit those with diabetes by reducing the production of glucose from non-carbohydrate sources. However, while it does have some advantages, such as antimicrobial and anti-inflammatory properties, its long-term use may be problematic due to toxicity in the liver and negative impacts on mitochondrial function. Urolithin A, a metabolite produced from the consumption of certain fruits, shows promise for improving mitochondrial health and gut integrity, but its effectiveness for weight loss in humans remains uncertain and largely based on animal studies.
Impact of Berberine on Blood Sugar Regulation
Berberine’s effects on blood sugar regulation are noteworthy, as it can induce a decrease in blood glucose levels by impairing mitochondrial function, which is generally not considered a healthy mechanism. The compound's inhition of gluconeogenesis, while beneficial for those with elevated glucose levels, results in decreased ATP production and ultimately leads to reliance on less efficient glycolysis for energy. This process can create an imbalance in the NADH/NAD+ ratio, which is unfavorable for optimal cellular function. Therefore, while berberine may assist in managing diabetes in the short term, its long-term implications on energy metabolism are questionable.
Effects of Urolithin A on Energy Production
Urolithin A has shown some potential benefits concerning energy production, particularly through studies suggesting enhancements in mitochondrial function and increased mitophagy, the process for mitochondria's repair and recycling. These mitochondrial benefits are thought to arise after gut bacteria metabolize certain dietary tannins found in foods like pomegranate and raspberries. However, some studies indicate that the benefits may be biased by commercial interests, emphasizing the need for caution regarding claims made about urolithin A's effects. Users should also note that individual responses to polyphenolic compounds, including urolithin A, can vary significantly based on unique microbiome compositions.
Considering Protein Intake with Carbohydrates
The combination of protein intake with carbohydrate consumption plays a crucial role in managing blood sugar levels. Generally, including protein can help stabilize blood sugar fluctuations by moderating the absorption rate of carbohydrates, making it particularly vital for individuals with insulin resistance or those prone to blood sugar spikes. However, while protein can mitigate large swings in blood sugar, it is essential to understand that slight fluctuations are often a normal and healthy part of metabolic functioning. Thus, individuals with healthy glucose metabolism may not require protein with every carbohydrate intake but should be aware of how their body responds to different food combinations.
The Role of Foundational Diet and Lifestyle Changes
The hosts emphasize that foundational health practices, including a balanced diet, proper sleep, and regular physical activity, are the most critical factors for effective weight management and overall health. Weight loss, especially for those severely overweight or dealing with metabolic syndrome, often improves significantly through simple lifestyle adjustments before supplemental aids are even considered. The focus should be on dietary quality rather than relying solely on supplements like berberine or urolithin A, as these may act more as adjuncts rather than primary solutions. A well-rounded approach prioritizing nutrient-dense foods, regular movement, and addressing hormonal health serves as the groundwork for achieving long-term health benefits.
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-122-weight-loss-with-berberine-and-urolithin-a-blood-sugar-spikes-and-pairing-protein-with-carbs-qa/
Timestamps:
0:00 – intro
1:10 – what are berberine and urolithin A?
2:26 – the benefits of berberine on gut health
9:06 – berberine as a mitochondrial poison and the mechanisms of berberine’s toxicity and blood-sugar-lowering effects
13:13 – of the effects urolithin A on mitochondria and the gut
18:15 – whether urolithin A is beneficial for weight loss and increases brown adipose tissue activity
22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits
26:31 – powerful weight loss strategies that are simple and effective, without supplementation
31:02 – whether we always need to avoid blood sugar spikes and dips
35:30 – when having protein alongside carbs is necessary and why increasing carbohydrate intake improves insulin sensitivity, even in people with type 2 diabetes
40:49 – how fat, fiber, and protein help slow the absorption of carbohydrates and improve blood sugar management
46:20 – issues with grain-based carbs and the importance of finding carb sources that work for you
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