The Intern At Work: Internal Medicine 175. The Internist's Guide to C.Difficile
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Dec 11, 2022 AI Snips
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Severity Classification of C. difficile
- C. difficile infection severity is classified by white blood cell count and serum creatinine levels.
- Fulminant cases involve hypotension, shock, ileus, or megacolon, indicating critical illness.
Preferred Treatment for Initial C. difficile
- Use fidaxomicin 200mg twice daily for 10 days as the preferred initial treatment for C. difficile.
- Vancomycin 125mg QID for 10 days is an alternative when fidaxomicin is unavailable.
Cost-Benefit of Fidaxomicin
- Although fidaxomicin is more expensive upfront, it reduces C. difficile recurrence rates.
- Long-term cost-effectiveness favors fidaxomicin due to fewer recurrences.