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- Fidaxomicin is prioritized over vancomycin for initial CDI episodes due to lower recurrence rates, but affordability may be an issue for some patients.
- Surgery is recommended for severe CDI cases with shock, ileus, or megacolon, with vancomycin and metronidazole as treatment options.
Deep dives
Management of Non-Severe and Severe C-Difficile Infection
The 2021 guidelines prioritize fidaxomicin over vancomycin for the initial episodes of CDI due to its superior reduction in recurrence rates. Fidaxomicin, though effective, may pose challenges in affordability for some patients compared to vancomycin, which remains a viable alternative especially in resource-constrained settings.
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