Supercharge your mitochondria, slash inflammation, and boost energy with one of the most overlooked hacks in human performance. This episode reveals how just 15 minutes of oxygen-based exercise can radically improve metabolism, brain optimization, and even reverse chronic conditions, without expensive gear or endless protocols.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Brad Pitzele, founder of One Thousand Roads and creator of the LEO System, an affordable and science-backed way to do Exercise With Oxygen Therapy (EWOT) at home. After nearly dying from autoimmune illness and failed functional medicine treatments, Brad used this oxygen-based biohacking tool to fully reboot his health. His story and system offer breakthrough potential for anyone facing fatigue, inflammation, or looking to upgrade energy, resilience, and longevity.
You’ll learn:
• How EWOT works differently from hyperbaric oxygen and why it’s faster
• Why brain fog, poor sleep, and chronic inflammation all trace back to oxygen supply
• How oxygen hacking activates neuroplasticity, detox pathways, and energy production
• When to stack with ketosis, red light, nootropics, and mitochondrial supplements
• How elite athletes and chronically ill patients both use this protocol
• Why “Smarter Not Harder” starts with oxygen-fueled mitochondrial upgrades
This is essential listening for anyone serious about biohacking, functional medicine, brain optimization, metabolism, fasting, supplements, and longevity.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
Get a free Ebook on EWOT to learn more today:
https://cdn.shopify.com/s/files/1/0097/3186/6683/files/The_Oxygen_Advantage_Protocol_-_EWOT.pdf?v=1752173567
SPONSORS:
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• One Thousand Roads Website: https://www.onethousandroads.com/
• One Thousand Roads YouTube (more info on EWOT) : https://www.youtube.com/@OneThousandRoadsHQ
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Labs: https://upgradelabs.com
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:10 Introduction
• 02:38 Discovering EWOT
• 03:55 Autoimmune Breakdown
• 06:54 Building One Thousand Roads
• 15:00 EWOT Science & Benefits
• 20:54 Protocols & Use Cases
• 29:03 Real-World Results
• 30:11 Brain Fog & Oxygen
• 30:58 Athletic Performance
• 31:41 Therapy Stacking
• 34:44 Mitochondria & Aging
• 37:08 Research & Studies
• 40:00 Future of Oxygen Therapy
• 43:02 Practical Tips & Access
• 51:09 Final Takeaways
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The Human Upgrade: Biohacking for Longevity & Performance 
