Pharmacy to Dose: The Critical Care Podcast

Acetaminophen Overdose

Apr 19, 2023

01:24:08

AI Chapters

Episode notes

Introduction

2min

Jimmy Leonard: The Assistant Director of the Maryland Poison Center and Associate Professor at the University of Maryland School of Pharmacy

2min

Acetaminophen Overdose: How to Manage It

2min

The Pathophysiology of Acetaminophen Induced Liver Injury

5min

The Importance of Timing in Acetaminophen Overdoses

3min

The Effect of C to a Minute Spin on Gastric Empty Time

4min

The Dangers of Extended Acetaminophen Concentrations

2min

The Concern About Activated Charcoal

4min

The Pros and Cons of Gastric Levage

2min

10.

The Importance of Whole-Value Irrigation

2min

11.

The Top 4 Decontamination Strategies

2min

12.

The Importance of a Four Hour Level of Medicine Concentration

2min

13.

Criteria for a Liver Transplant

2min

14.

Phos Is the Forgotten Electrolyte

2min

15.

The Future of Acetaminophen Overdose

2min

16.

The Role of Enecetal Sistine in Napkin Production

2min

17.

The Role of Oral Nack in the Treatment of Sick Patients

3min

18.

The Standard Dosing Regimen for NAC Overdose

3min

19.

The Importance of One Bag Treatment

2min

20.

Non-Allergic Anaphylactic Reactions to NAC

2min

21.

The Importance of Standardization

2min

22.

How to Overdose Safely

2min

23.

How to Calculate the Dose of a Drug

3min

24.

How to Increase Your Ingestion Rate

1min

25.

The Effects of NAC on INR

3min

26.

The Importance of Dose Caps in Detoxification

3min

27.

The Importance of Dose Adjustments in Hemodialysis

3min

28.

Acetaminophen Overdose and Its Effects on Labs

2min

29.

The New Kid on the Block: Meppazole and Acetaminophen

2min

30.

The Role of Acetaminophen in Massive Overdose

2min

31.

Acetylcysteine and the Dose Cap IV

2min

32.

The Rise of Fumepazole Use

3min

33.

How to Treat a C-Daminophen Overdose Patient

4min

Acetaminophen Overdose

Special Guest: Jimmy Leonard, PharmD, DABAT

Poison Center: 1-800-222-1222

05:11 – Patient Case Intro

06:46 – Pathophysiology and Nomogram

21:55 – GI Decontamination

29:10 – Labs & Signs/Symptoms

35:55 – Historical Treatments

37:10 – N-acetylcysteine (NAC)

66:30 – Adjunctive Treatments

77:50 – Ultimate Take-Away

Reference List: https://pharmacytodose.files.wordpress.com/2023/04/acetaminophen-overdose-references.pdf

PharmacyToDose.Com

@PharmacyToDose

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