The Pathophysiology of Acetaminophen Induced Liver Injury

acetaminophen when you ingest it is primarily metabolized to or via glucuronization about 50 percent. And then another 5 percent goes through your SIP metabolism, right? And this is your scary SIP 2e1, sometimes 1a2 and a little bit of 3a4. In massive overdose though, and we'll talk about that later, we actually think that this like production of glutathione where you're trying to help recycle it will cause really rapid turnover and utilization of ATP. We also think that acetaminophen might uncouple oxidative phosphorylation, which is really important for energy production. This could have effects like an early metabolic acidosis and early really high lact