The Peter Attia Drive

#291 ‒ The role of testosterone in males and females, performance-enhancing drugs, sustainable fat loss, supplements, and more | Derek, More Plates More Dates Pt.2

289 snips
Feb 26, 2024
Derek, the fitness educator behind More Plates More Dates, returns to share his insights on hormones and their impact on health. He dives deep into the roles of testosterone, DHT, and DHEA in both men and women, discussing the complexities and risks of testosterone therapy for women. Derek also explores the latest trends in muscle growth, including the myostatin-follistatin debate, and offers strategies for sustainable fat loss without sacrificing muscle. He emphasizes the importance of accurate hormone testing and the potential dangers of gray market peptides.
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ADVICE

Women's TRT and Acne

  • If you're a woman on TRT, monitor for acne, as it indicates a potentially excessive dose.
  • Adjust the dose as needed to find what works for you, avoiding overly high levels.
INSIGHT

Measuring DHEA

  • DHEA-sulfate (DHEA-S) levels are measured as a proxy for DHEA, similar to how IGF-1 reflects GH levels.
  • Direct DHEA measurement is not as indicative of the total body pool.
ADVICE

Finding the Right Progesterone Dose

  • Find the right progesterone dose for each woman individually, as it significantly impacts mood and well-being.
  • Consider a Mirena IUD as a backup if a suitable progesterone dose can't be found.
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