FoundMyFitness #038 Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation
Jul 31, 2017
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Autophagy Overview
- Autophagy, a cellular self-eating process, is triggered by stress and nutrient deprivation.
- It involves sequestering and digesting cytoplasmic portions, including organelles and protein aggregates, for recycling and energy generation.
Autophagy's Purpose
- Initially thought to cause cell death, autophagy is now understood as a cellular adaptation to stress.
- Its primary goal is to avoid cell death by recycling cellular components and generating energy under stress conditions.
Nutrient Deprivation and Autophagy
- Autophagy is primarily triggered by nutrient deprivation, a fundamental stressor.
- Lack of nutrients, growth factors, or oxygen can induce autophagy, prompting cells to break down their reserves for energy.