Lex Fridman Podcast

#133 – Manolis Kellis: Biology of Disease

Oct 25, 2020

Manolis Kellis, a computational biologist at MIT, shares expert insights into the complexities of human disease and genetics. He discusses how genetics plays a crucial role in understanding and treating diseases, highlighting the significance of perturbation experiments over traditional model organisms. Kellis also tackles the interplay between genetic variations, lifestyle factors, and public health, emphasizing the need for collective efforts to improve health outcomes. His exploration of cutting-edge genomic technologies, like CRISPR, reveals exciting advancements in disease research.

02:40:24

Creator website

Episode guests

Manolis Kellis

Highlights

AI Chapters

Episode notes

The Complexity of Understanding Genetic Diseases

01:06

Localization of genetic variants associated with different health traits

01:34

Understanding Genetic Perturbations: Steps to Finding Target Genes

01:26

The Role of irXtN and irX5 in Thermogenesis and Fat Generation

01:53

Intro

2min

Rethinking Computational Systems and Podcast Sponsorships

2min

Understanding Historical Resistance to Innovation

3min

Exploring the Complexity of Human Disease Through Genetics

5min

Unraveling Genetic Complexity in Disease

19min

Understanding Disease: Genetics, Lifestyle, and Public Health

13min

The Interplay of Genetics and Disease: Strong and Weak Effects

2min

Genetics, Immunity, and Disease Interconnections

10min

Unifying Understanding of Disease through Genetics

24min

10.

Genetics and Obesity: Mechanisms and Innovations

23min

11.

Genes, Mitochondria, and Obesity

9min

12.

Advancements in Genomic Technologies

19min

13.

Interdisciplinary Innovations in Disease Research

26min

14.

Envisioning Future Human Experiences

2min

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:
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EPISODE LINKS:
Manolis Website: http://web.mit.edu/manoli/
Manolis Twitter: https://twitter.com/manoliskellis
Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA
Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis

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OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
08:05 – Molecular basis for human disease
32:04 – Deadliest diseases
37:47 – Genetic component of diseases
46:38 – Genetic understanding of disease
1:02:25 – Unified theory of human disease
1:08:26 – Genome circuitry
1:33:29 – CRISPR
1:45:06 – Mitochondria
1:53:10 – Future of biology research
2:22:46 – The genetic circuitry of disease

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