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#133 – Manolis Kellis: Biology of Disease

Lex Fridman Podcast

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Unraveling Genetic Complexity in Disease

This chapter explores the intricate relationship between genetic variations and human diseases, emphasizing the challenges of understanding these connections compared to simpler animal studies. It highlights the evolution of genetic research methods, the significance of modern tools for exploring cellular roles in diseases like Alzheimer's, and the interplay between genetics and epigenetics. Additionally, the chapter discusses the importance of comprehensive health metrics and phenotyping to capture a nuanced view of cognitive traits influenced by multiple genes.

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