Understanding Historical Resistance to Innovation

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:
– SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru
– Pessimists Archive: https://pessimists.co/
– Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get $200 off
– BetterHelp: https://betterhelp.com/lex to get 10% off

EPISODE LINKS:
Manolis Website: http://web.mit.edu/manoli/
Manolis Twitter: https://twitter.com/manoliskellis
Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA
Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast
Apple Podcasts: https://apple.co/2lwqZIr
Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
YouTube Full Episodes: https://youtube.com/lexfridman
YouTube Clips: https://youtube.com/lexclips

SUPPORT & CONNECT:
– Check out the sponsors above, it’s the best way to support this podcast
– Support on Patreon: https://www.patreon.com/lexfridman
– Twitter: https://twitter.com/lexfridman
– Instagram: https://www.instagram.com/lexfridman
– LinkedIn: https://www.linkedin.com/in/lexfridman
– Facebook: https://www.facebook.com/LexFridmanPage
– Medium: https://medium.com/@lexfridman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
08:05 – Molecular basis for human disease
32:04 – Deadliest diseases
37:47 – Genetic component of diseases
46:38 – Genetic understanding of disease
1:02:25 – Unified theory of human disease
1:08:26 – Genome circuitry
1:33:29 – CRISPR
1:45:06 – Mitochondria
1:53:10 – Future of biology research
2:22:46 – The genetic circuitry of disease