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#133 – Manolis Kellis: Biology of Disease

Lex Fridman Podcast

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Unifying Understanding of Disease through Genetics

This chapter explores the critical role of genetics in understanding and treating various diseases, emphasizing interdisciplinary collaboration in biomedical research. It highlights the complexity of genetic interactions and the significance of studying tissue-specific effects of non-coding variants, exemplified by the FTO gene related to obesity. The discussion underscores the importance of a holistic approach to genome analysis, revealing shared mechanisms across different disorders like Alzheimer's and schizophrenia.

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